IRS4_YARLI
ID IRS4_YARLI Reviewed; 1005 AA.
AC Q6C449;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Increased rDNA silencing protein 4;
GN Name=IRS4; OrderedLocusNames=YALI0E29689g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC turnover and negatively regulates signaling through the cell integrity
CC pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR EMBL; CR382131; CAG80167.1; -; Genomic_DNA.
DR RefSeq; XP_504563.1; XM_504563.1.
DR AlphaFoldDB; Q6C449; -.
DR SMR; Q6C449; -.
DR STRING; 4952.CAG80167; -.
DR PRIDE; Q6C449; -.
DR EnsemblFungi; CAG80167; CAG80167; YALI0_E29689g.
DR GeneID; 2911937; -.
DR KEGG; yli:YALI0E29689g; -.
DR VEuPathDB; FungiDB:YALI0_E29689g; -.
DR HOGENOM; CLU_298802_0_0_1; -.
DR InParanoid; Q6C449; -.
DR Proteomes; UP000001300; Chromosome E.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR Pfam; PF12763; EF-hand_4; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50031; EH; 1.
PE 3: Inferred from homology;
KW Lipid metabolism; Reference proteome.
FT CHAIN 1..1005
FT /note="Increased rDNA silencing protein 4"
FT /id="PRO_0000308766"
FT DOMAIN 845..934
FT /note="EH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT REGION 1..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..54
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..425
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 609..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..960
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..1005
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 110190 MW; C6196D76C07A3E8C CRC64;
MSALSASLAA AAAAARASET SRESNNVAVT KARPPQHTLV KPAPAKPPRP VARRPKQPVK
ITVDTSVANT PAPQGSSATS AAAAAARHFK KQKDEQSSPK LSPHHRPPAS HRNSGESAKT
PSSDSRPAST TSTIPVTPVS ATTPSSTVAA AASAAAKRSS TFNKSVPTPV VSDIMKKEQE
ENRAAAAAAA AQEKATQIIR DLPSPSNSVR SKRLSQSSLV PVLSDEDIYN HRRYARSSQS
FATIPTDEDS PGEMGDFEDN NQVHRERARG IQSAAKHANR LSQTSMDSTH TSQQLQPVVS
PHTGLPQEGS VLAAALKAGS NASSTMERIS LTNEAKEREK AEKRQRKDAK AKAKLLAQAN
AVYQQSTNES HHAHHHQYHQ GNIFKRVIGK SGKPIDPFQG FSPNFSERPG EHFHNHQREM
QGAPDGIRRS MDTSRQSIDA PRQSLDAARQ SIDTPRELTT NDTSPIPIQP LKSHDAGAVS
DLPTSLDEPG LSGHPHLQQS FSNNNALQTV KSSTDDSMSI ASLDSVDDSG PGRPPLLAPI
PIRNASIIPV SSESESEDIR RGHRRHLSSS QSQRNSLQFP MSPTFSASPA KQLITPEQLL
PKRRRGIART PSVSSSAPRS SSPVISIPLE RSSTLQSTLQ GSPMNSPVAK SPVFFEGNNG
STNGGLGSSM SNSPPDSELA LTPSESTAHS YFAREYREPK SSSTRGVEGA SRLAKKLPHR
HLAAGGKSIV KSIWNKATPD APPPPPVSTG GMKTSLRKQP KKKFNEDKPW KHHNDADTLT
DADRKRYDGV WATNRGAHVP YYMEPEEYDI LIDEEEFYDE GFLSDSDFTD SDSDDDSVSS
AEYIMSGENI GNDDVVVSDQ NDAVHGYIVS RLWRRSRLPD ERLSDIWELV DRCNDGTLDR
EGFLVGMWLV DQCLYGRKLP NKVDPRVWGS VGRLNVNIKI RQKEPKRNSA KRKARRKVRR
DRKELVRERE RNEKERRKDE KKEKKDEKKD KKDDRRRDKK RVGEA
