ID   IRS4_YEAS7              Reviewed;         615 AA.
AC   A6ZZY3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; ORFNames=SCY_3393;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: With TAX4, acts as a positive regulator of INP51 activity and
CC       phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates
CC       signaling through the cell integrity pathway, including the MAP kinase
CC       SLT2. Seems also to be involved in rDNA silencing (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with INP51. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; AAFW02000152; EDN59926.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZZY3; -.
DR   SMR; A6ZZY3; -.
DR   PRIDE; A6ZZY3; -.
DR   EnsemblFungi; EDN59926; EDN59926; SCY_3393.
DR   HOGENOM; CLU_454275_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Phosphoprotein.
FT   CHAIN           1..615
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308767"
FT   DOMAIN          460..571
FT                   /note="EH"
FT   REGION          38..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          277..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          323..445
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..300
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..370
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..436
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         180
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P36115"
SQ   SEQUENCE   615 AA;  68910 MW;  3EB0818990F068FD CRC64;
     MRLSFGKQRY HGGTTVTLTE QGASDSLRAA QAIFQNHSNE VSSPCPPVTV SRNPQTRLSE
     PSLQKSGRKQ EQKKARIRTK QVPKIKTTAP NDVELSKKHR SSPAGKDNVS STAQMAAALA
     HSQSKLSSDN NSSHSSALDT LKVLETPNLN GLLGIHSRSS SRNGSNESLT PGQRTPDNRS
     QENLLTSFSS GRRLSSSSME PATNKDSNKA LPKRRPSPPL QSSLVGSGQL HENENLSSIS
     IDSRHSLNPD TSDVISNRSQ TSLSQTINQL SLCESEPSIA SSNTTTTTSN QGSGLPNLVP
     NYSSDMRKKK LVNKFKRKVF GSKPKHLSSQ YEMDASSEEL GQHEQQPSMR FKTTLRKTSV
     STNAENDHAS SLHEGNLRYK YNPSNDTYDV YDDTDSDSES DQNQDALTKP RKRDRIKRKI
     RNSANKTAHH RPIHRTRDRK FNEDKPWKSH TDITFVTDNE RKRYESMWVS NRHRHLNLLS
     WWPSLTGDSG AINTLPEDGL ILGIIVRDIW KRSNLPNSLL AEIYTKVDTR KDGTLDRKSF
     IVGMWLVDQC LYGRKLPNVV EQCVWDSVDR YASTMVVPVS TLKAMAKQKR KQMKEEIKNI
     KKENRVVLVD HNSSS