APRR2_ARATH
ID APRR2_ARATH Reviewed; 535 AA.
AC Q6LA43; O49701; Q94F45;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 2.
DT 25-MAY-2022, entry version 141.
DE RecName: Full=Two-component response regulator-like APRR2;
DE AltName: Full=Pseudo-response regulator 2;
DE AltName: Full=TOC2 protein;
GN Name=APRR2; Synonyms=TOC2; OrderedLocusNames=At4g18020; ORFNames=T6K21.200;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND GENE FAMILY.
RC STRAIN=cv. Columbia;
RX PubMed=10945350; DOI=10.1093/pcp/41.6.791;
RA Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T.,
RA Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.;
RT "Genes encoding pseudo-response regulators: insight into His-to-Asp
RT phosphorelay and circadian rhythm in Arabidopsis thaliana.";
RL Plant Cell Physiol. 41:791-803(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Transcriptional activator that binds specifically to the DNA
CC sequence 5'-[AG]GATT-3'. {ECO:0000250}.
CC -!- SUBUNIT: Binds the target DNA as a monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6LA43-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6LA43-2; Sequence=VSP_011629;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice
CC site. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ARR-like family. {ECO:0000305}.
CC -!- CAUTION: Lacks the phospho-accepting Asp (here Glu-76), present in the
CC receiver domain, which is one of the conserved features of the two-
CC component response regulators (ARRs) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA17145.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78804.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB041531; BAA94548.1; -; mRNA.
DR EMBL; AL021889; CAA17145.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161547; CAB78804.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83980.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83981.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83982.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83983.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83984.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE83985.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67513.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67514.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67515.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67516.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67517.1; -; Genomic_DNA.
DR EMBL; AF385725; AAK60316.1; -; mRNA.
DR EMBL; AY143963; AAN28902.1; -; mRNA.
DR PIR; T05088; T05088.
DR RefSeq; NP_001078405.1; NM_001084936.2. [Q6LA43-2]
DR RefSeq; NP_001154250.1; NM_001160778.2. [Q6LA43-2]
DR RefSeq; NP_001190759.1; NM_001203830.1. [Q6LA43-1]
DR RefSeq; NP_001329339.1; NM_001341254.1. [Q6LA43-2]
DR RefSeq; NP_001329340.1; NM_001341255.1. [Q6LA43-2]
DR RefSeq; NP_001329341.1; NM_001341256.1. [Q6LA43-1]
DR RefSeq; NP_001329342.1; NM_001341252.1. [Q6LA43-2]
DR RefSeq; NP_001329343.1; NM_001341253.1. [Q6LA43-2]
DR RefSeq; NP_567548.1; NM_117912.4. [Q6LA43-1]
DR RefSeq; NP_849403.1; NM_179072.3. [Q6LA43-1]
DR RefSeq; NP_849404.2; NM_179073.4. [Q6LA43-1]
DR AlphaFoldDB; Q6LA43; -.
DR SMR; Q6LA43; -.
DR BioGRID; 12820; 4.
DR IntAct; Q6LA43; 1.
DR STRING; 3702.AT4G18020.6; -.
DR PaxDb; Q6LA43; -.
DR PRIDE; Q6LA43; -.
DR ProteomicsDB; 240601; -. [Q6LA43-1]
DR EnsemblPlants; AT4G18020.1; AT4G18020.1; AT4G18020. [Q6LA43-1]
DR EnsemblPlants; AT4G18020.10; AT4G18020.10; AT4G18020. [Q6LA43-2]
DR EnsemblPlants; AT4G18020.11; AT4G18020.11; AT4G18020. [Q6LA43-2]
DR EnsemblPlants; AT4G18020.2; AT4G18020.2; AT4G18020. [Q6LA43-1]
DR EnsemblPlants; AT4G18020.3; AT4G18020.3; AT4G18020. [Q6LA43-1]
DR EnsemblPlants; AT4G18020.4; AT4G18020.4; AT4G18020. [Q6LA43-2]
DR EnsemblPlants; AT4G18020.5; AT4G18020.5; AT4G18020. [Q6LA43-2]
DR EnsemblPlants; AT4G18020.6; AT4G18020.6; AT4G18020. [Q6LA43-1]
DR EnsemblPlants; AT4G18020.7; AT4G18020.7; AT4G18020. [Q6LA43-2]
DR EnsemblPlants; AT4G18020.8; AT4G18020.8; AT4G18020. [Q6LA43-2]
DR EnsemblPlants; AT4G18020.9; AT4G18020.9; AT4G18020. [Q6LA43-1]
DR GeneID; 827527; -.
DR Gramene; AT4G18020.1; AT4G18020.1; AT4G18020. [Q6LA43-1]
DR Gramene; AT4G18020.10; AT4G18020.10; AT4G18020. [Q6LA43-2]
DR Gramene; AT4G18020.11; AT4G18020.11; AT4G18020. [Q6LA43-2]
DR Gramene; AT4G18020.2; AT4G18020.2; AT4G18020. [Q6LA43-1]
DR Gramene; AT4G18020.3; AT4G18020.3; AT4G18020. [Q6LA43-1]
DR Gramene; AT4G18020.4; AT4G18020.4; AT4G18020. [Q6LA43-2]
DR Gramene; AT4G18020.5; AT4G18020.5; AT4G18020. [Q6LA43-2]
DR Gramene; AT4G18020.6; AT4G18020.6; AT4G18020. [Q6LA43-1]
DR Gramene; AT4G18020.7; AT4G18020.7; AT4G18020. [Q6LA43-2]
DR Gramene; AT4G18020.8; AT4G18020.8; AT4G18020. [Q6LA43-2]
DR Gramene; AT4G18020.9; AT4G18020.9; AT4G18020. [Q6LA43-1]
DR KEGG; ath:AT4G18020; -.
DR Araport; AT4G18020; -.
DR TAIR; locus:2141020; AT4G18020.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_034607_0_0_1; -.
DR InParanoid; Q6LA43; -.
DR OMA; MWGSPGY; -.
DR OrthoDB; 737823at2759; -.
DR PhylomeDB; Q6LA43; -.
DR PRO; PR:Q6LA43; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q6LA43; baseline and differential.
DR Genevisible; Q6LA43; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR044825; GLK1/2-like.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR31312; PTHR31312; 2.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..535
FT /note="Two-component response regulator-like APRR2"
FT /id="PRO_0000132304"
FT DOMAIN 25..139
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 298..348
FT /note="Myb-like GARP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 206..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 478..535
FT /note="DEEMLDQVVKEAISKPWLPLPLGLKPPSAESVLAELTRQGISAVPSSSCLIN
FT GSHRLR -> VSVNNSLFSF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10945350"
FT /id="VSP_011629"
SQ SEQUENCE 535 AA; 59402 MW; 5DB1EDA6A130418A CRC64;
MVITANDLSK WENFPKGLKV LLLLNGCDSD GDGSSAAETR SELESMDYIV TTFTDETEAL
SAVVKNPESF HIAIVEVNMS AESESFKFLE AAKDVLPTIM ISTDHCITTT MKCIALGAVE
FLQKPLSPEK LKNIWQHVVH KAFNDGGSNV SISLKPVKES VVSMLHLETD MTIEEKDPAP
STPQLKQDSR LLDGDCQENI NFSMENVNSS TEKDNMEDHQ DIGESKSVDT TNRKLDDDKV
VVKEERGDSE KEEEGETGDL ISEKTDSVDI HKKEDETKPI NKSSGIKNVS GNKTSRKKVD
WTPELHKKFV QAVEQLGVDQ AIPSRILELM KVGTLTRHNV ASHLQKFRQH RKNILPKDDH
NHRWIQSREN HRPNQRNYNV FQQQHRPVMA YPVWGLPGVY PPGAIPPLWP PPLQSIGQPP
PWHWKPPYPT VSGNAWGCPV GPPVTGSYIT PSNTTAGGFQ YPNGAETGFK IMPASQPDEE
MLDQVVKEAI SKPWLPLPLG LKPPSAESVL AELTRQGISA VPSSSCLING SHRLR
