IRX1B_XENLA
ID IRX1B_XENLA Reviewed; 462 AA.
AC Q2TAQ8;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Iroquois-class homeodomain protein irx-1-B;
DE AltName: Full=Iroquois homeobox protein 1-B;
GN Name=irx1-b; Synonyms=iro1-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000312|EMBL:AAI10768.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neurula {ECO:0000312|EMBL:AAI10768.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts partially redundantly with other irx members in neural
CC patterning. Required for formation of the posterior forebrain,
CC midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in
CC neural plate development to induce expression of some but not all
CC proneural genes, and specify a neural precursor state. Also up-
CC regulates repressors that prevent neuronal differentiation. Patterns
CC the neuroectoderm in both the anterior/posterior and dorsal/ventral
CC axes. Acts primarily as a transcriptional repressor during neural
CC development, and binds to the bmp4 promoter to repress gene expression
CC and thus mediate down-regulation of bmp4 by wnt signaling. Controls
CC multiple processes through bmp4-repression including neural plate
CC development, neural crest specification and Spemann organizer
CC development. Involved in the specification of the preplacodal field at
CC the anterior border of the neural plate. Regulates the genetic cascade
CC of interactions that are necessary for positioning the isthmus
CC organizer and the formation of the midbrain-hindbrain boundary.
CC Required during at least two stages of pronephros kidney development;
CC during neurula stages, maintains transcription of key renal genes to
CC define the size and identity of the pronephric anlage, probably in part
CC through regulation of bmp-signaling. Subsequently required for proper
CC formation of the intermediate tubule segment of the pronephros. Acts
CC principally as a transcriptional activator during pronephros
CC development (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000255}.
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DR EMBL; BC110767; AAI10768.1; -; mRNA.
DR RefSeq; NP_001090157.1; NM_001096688.1.
DR AlphaFoldDB; Q2TAQ8; -.
DR SMR; Q2TAQ8; -.
DR DNASU; 735237; -.
DR GeneID; 735237; -.
DR KEGG; xla:735237; -.
DR CTD; 735237; -.
DR Xenbase; XB-GENE-6254076; irx1.S.
DR OrthoDB; 827009at2759; -.
DR Proteomes; UP000186698; Chromosome 6S.
DR Bgee; 735237; Expressed in gastrula and 8 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR GO; GO:0001708; P:cell fate specification; ISS:UniProtKB.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR GO; GO:0072005; P:maintenance of kidney identity; ISS:UniProtKB.
DR GO; GO:0007498; P:mesoderm development; ISS:UniProtKB.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; ISS:UniProtKB.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0014036; P:neural crest cell fate specification; ISS:UniProtKB.
DR GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0009954; P:proximal/distal pattern formation; ISS:UniProtKB.
DR GO; GO:0072196; P:proximal/distal pattern formation involved in pronephric nephron development; ISS:UniProtKB.
DR GO; GO:0039005; P:specification of pronephric tubule identity; ISS:UniProtKB.
DR GO; GO:0060062; P:Spemann organizer formation at the dorsal lip of the blastopore; ISS:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..462
FT /note="Iroquois-class homeodomain protein irx-1-B"
FT /id="PRO_0000388714"
FT DNA_BIND 121..183
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 191..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..236
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 237..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 50396 MW; 2107F71F3D3937BD CRC64;
MSFPQLGYPQ YLTAGQGAVY GGERPGVLAA AAAAAAAAGR PTGAELGSCP TAAVTSVLGM
YASPYSSPNY SAFLPYTTDL TLFSQMGSQY ELKDNPGVHP ATFAAHTTPG YYPYGQFQYG
DPGRPKNATR ESTSTLKAWL NEHRKNPYPT KGEKIMLAII TKMTLTQVST WFANARRRLK
KENKVTWGAM GKEDDNIFGS DNEGDHEKNE DDEEIDLESI DIDKIDDNDG EQSNEEEDEK
LDHFRHGEKV SLKKESEVMI PSSDGLKPKD SLSLGKECSD TSNTRIVSPG GQGNIQAPPH
SKPKIWSLAE TATSPDGALK SSPPPSQANH TSPQMQHPAF LPSHGLYTCQ IGKFHNWTNG
AFLTQSSLIN MRSLLGVNPH HAAHHNHHHL QAHQQSTLLA TNLGSLSSDR TPERTSPKHS
DRENLPRTES PPQLKPSFQA VREKTFSQQE GTSRILTALP SA
