IRX4A_XENLA
ID IRX4A_XENLA Reviewed; 496 AA.
AC Q90XW6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Iroquois-class homeodomain protein irx-4-A;
DE AltName: Full=Iroquois homeobox protein 4-A;
GN Name=irx4-a; Synonyms=irx4 {ECO:0000312|EMBL:AAK96065.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK96065.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Tadpole {ECO:0000269|PubMed:11455441};
RX PubMed=11455441; DOI=10.1007/s004270100147;
RA Garriock R.J., Vokes S.A., Small E.M., Larson R., Krieg P.A.;
RT "Developmental expression of the Xenopus Iroquois-family homeobox genes,
RT Irx4 and Irx5.";
RL Dev. Genes Evol. 211:257-260(2001).
RN [2] {ECO:0000305}
RP LACK OF EXPRESSION IN THE PRONEPHROS.
RX PubMed=17875669; DOI=10.1101/gad.450707;
RA Reggiani L., Raciti D., Airik R., Kispert A., Braendli A.W.;
RT "The prepattern transcription factor Irx3 directs nephron segment
RT identity.";
RL Genes Dev. 21:2358-2370(2007).
RN [3] {ECO:0000305}
RP LACK OF REQUIREMENT FOR PRONEPHROS DEVELOPMENT, AND TISSUE SPECIFICITY.
RX PubMed=18715948; DOI=10.1242/dev.023697;
RA Alarcon P., Rodriguez-Seguel E., Fernandez-Gonzalez A., Rubio R.,
RA Gomez-Skarmeta J.L.;
RT "A dual requirement for Iroquois genes during Xenopus kidney development.";
RL Development 135:3197-3207(2008).
RN [4] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=19268445; DOI=10.1016/j.ydbio.2009.02.028;
RA Rodriguez-Seguel E., Alarcon P., Gomez-Skarmeta J.L.;
RT "The Xenopus Irx genes are essential for neural patterning and define the
RT border between prethalamus and thalamus through mutual antagonism with the
RT anterior repressors Fezf and Arx.";
RL Dev. Biol. 329:258-268(2009).
CC -!- FUNCTION: Acts partially redundantly with other irx members in neural
CC patterning. Required for formation of the posterior forebrain,
CC midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the
CC neuroectoderm in both the anterior/posterior and dorsal/ventral axes.
CC Does not appear to play a role in pronephros kidney development.
CC {ECO:0000269|PubMed:18715948, ECO:0000269|PubMed:19268445}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the neural plate in overlapping
CC patterns with other irx members, which all share an anterior border of
CC expression. At stage 20, expressed in a subset of cells in the
CC developing hindbrain with expression appearing above the otic vesicle
CC by stage 26. Expression in retina cells begins at stage 28, continuing
CC at later stages and is limited to a subset of retinal cells of the
CC optic cup. Also expressed in the ventricle of the heart from stage 36
CC (late tailbud) onwards. Only expressed in the pronephros at tadpole
CC stage. {ECO:0000269|PubMed:11455441, ECO:0000269|PubMed:18715948,
CC ECO:0000269|PubMed:19268445}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF338157; AAK96065.1; -; mRNA.
DR RefSeq; NP_001090204.1; NM_001096735.1.
DR AlphaFoldDB; Q90XW6; -.
DR SMR; Q90XW6; -.
DR GeneID; 779102; -.
DR KEGG; xla:779102; -.
DR CTD; 779102; -.
DR Xenbase; XB-GENE-865388; irx4.L.
DR OMA; QQAKSCY; -.
DR OrthoDB; 814237at2759; -.
DR Proteomes; UP000186698; Chromosome 6L.
DR Bgee; 779102; Expressed in heart and 4 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:UniProtKB.
DR GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR GO; GO:0009954; P:proximal/distal pattern formation; IMP:UniProtKB.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Homeobox;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..496
FT /note="Iroquois-class homeodomain protein irx-4-A"
FT /id="PRO_0000388718"
FT DNA_BIND 141..203
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 203..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 55524 MW; AB66AB5BBA01DAFA CRC64;
MSYPQFGYPY SSTPQFLMTT NSLSTCCESS GRSLSDSAAA ASAQTPVYCP VYESRLLATA
RHELNSAAAL GVYGNPYTST QGYGNYVTYG ADASAFYSLN AFESKDGTGS AHAGIPQTAA
YYPYEHTLSQ YQYDRYGTMD GSSRRKNATR ETTSTLKAWL QEHRKNPYPT KGEKIMLAII
TKMTLTQVST WFANARRRLK KENKMTWPPR NKCSDEKRPY DEEEEEEEEE EDSQKATIKN
EKKTVDEEVV REDKALDLSD LEDFDTIESE SSECELKQPF HHQPQDGHQL RQRDCVNDHC
KDVILKMPLN STVNQELDRT NICLKSGVDQ CEQDVLRGRQ RSGESKACFQ QQQILDSKPR
IWSLAHTATS LNQTEYPSCM LKHQGLSSPS SSSSSSAVST PVCVIDRRQD SPVTSLRNWV
DGVFHDPLFR HSTLNQALTN TTVSWATTKG TLIDSGSLGR SVGNPTNVKG QLPNIPHDTN
KEFIAFQKSG SKMFCS
