ID   IRX4B_XENLA             Reviewed;         495 AA.
AC   B7ZRT8;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Iroquois-class homeodomain protein irx-4-B;
DE   AltName: Full=Iroquois homeobox protein 4-B;
GN   Name=irx4-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000312|EMBL:AAI70284.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts partially redundantly with other irx members in neural
CC       patterning. Required for formation of the posterior forebrain,
CC       midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the
CC       neuroectoderm in both the anterior/posterior and dorsal/ventral axes.
CC       Does not appear to play a role in pronephros kidney development (By
CC       similarity). {ECO:0000250|UniProtKB:Q90XW6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000255}.
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DR   EMBL; BC170284; AAI70284.1; -; mRNA.
DR   RefSeq; NP_001154863.1; NM_001161391.1.
DR   RefSeq; XP_018124032.1; XM_018268543.1.
DR   RefSeq; XP_018124033.1; XM_018268544.1.
DR   AlphaFoldDB; B7ZRT8; -.
DR   SMR; B7ZRT8; -.
DR   GeneID; 100301956; -.
DR   KEGG; xla:100301956; -.
DR   CTD; 100301956; -.
DR   Xenbase; XB-GENE-6448215; irx4.S.
DR   OrthoDB; 814237at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 100301956; Expressed in heart and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEA:UniProt.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:UniProt.
DR   GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR   GO; GO:0009954; P:proximal/distal pattern formation; IEA:UniProt.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR003893; Iroquois_homeo.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00548; IRO; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..495
FT                   /note="Iroquois-class homeodomain protein irx-4-B"
FT                   /id="PRO_0000388719"
FT   DNA_BIND        141..203
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          203..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..219
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   495 AA;  55402 MW;  4969BAB8940DD3CF CRC64;
     MSYPQFGYPY SSTPQFLMTT NSLSTCCESN GRSLSDSAAA ASAQTPVYCP VYESRLLATA
     RHELNSAAAL GVYGSPYTST QGYGNYVTYG ADAPSFYSLN AFESKDGTGS AHAGIPQTAA
     YYPYEHTLSQ YQYDRYGTMD GSTRRKNATR ETTSTLKAWL QEHRKNPYPT KGEKIMLAII
     TKMTLTQVST WFANARRRLK KENKMTWPPR NKCSDEKRPY DEEEEEEEDS QKATIKNEKK
     TVDEEIHREE KALDLSDLED FDTIESESSE CELKQPFHHQ PQDGHQLRQR DCVNDHCKEV
     ILKMPITSTA TQELDRTKIC HKTGLDQCEQ DLLRGRQRGG GESKSCFQQQ QILDSKPRIW
     SLAHTATSLN QTEYPSCMLK HQGLSSPSSS SSSSAVSTPV CVIDRRQDSP VTSLRNWVDG
     VFHDPLFRHS TLNQALTNTT VSWATTKGTL IDSGSLGRSV GNSTNVIKGQ LPNLPHDTNK
     EFIAFQTSGS KMFCS