ID   IRX5_XENTR              Reviewed;         482 AA.
AC   Q4LDQ3;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Iroquois-class homeodomain protein irx-5 {ECO:0000250|UniProtKB:Q90XW5};
DE   AltName: Full=Iroquois homeobox protein 5 {ECO:0000250|UniProtKB:P78411};
GN   Name=irx5 {ECO:0000250|UniProtKB:Q90XW5};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAY89592.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT   "Sequence of Xenopus tropicalis development genes.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=19268445; DOI=10.1016/j.ydbio.2009.02.028;
RA   Rodriguez-Seguel E., Alarcon P., Gomez-Skarmeta J.L.;
RT   "The Xenopus Irx genes are essential for neural patterning and define the
RT   border between prethalamus and thalamus through mutual antagonism with the
RT   anterior repressors Fezf and Arx.";
RL   Dev. Biol. 329:258-268(2009).
CC   -!- FUNCTION: Acts partially redundantly with other irx members in neural
CC       patterning. Required for formation of the posterior forebrain,
CC       midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the
CC       neuroectoderm in both the anterior/posterior and dorsal/ventral axes.
CC       Does not appear to play a role in pronephros kidney development.
CC       Involved in craniofacial and gonadal development (By similarity).
CC       Modulates the migration of progenitor cell populations in branchial
CC       arches and gonads by repressing CXCL12. {ECO:0000250,
CC       ECO:0000269|PubMed:19268445}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the neural plate in overlapping
CC       patterns with other irx members, which all share an anterior border of
CC       expression. Broadly expressed in the tailbud rhombencephalon
CC       (hindbrain). Outside the nervous system and at tailbud stages,
CC       expressed in the developing otic vesicle and branchial arches.
CC       {ECO:0000269|PubMed:19268445}.
CC   -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC160824; AAY89592.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4LDQ3; -.
DR   SMR; Q4LDQ3; -.
DR   STRING; 8364.ENSXETP00000006137; -.
DR   PaxDb; Q4LDQ3; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   HOGENOM; CLU_048118_0_0_1; -.
DR   InParanoid; Q4LDQ3; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; ISS:UniProtKB.
DR   GO; GO:0048468; P:cell development; IBA:GO_Central.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; ISS:UniProtKB.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISS:UniProtKB.
DR   GO; GO:0008406; P:gonad development; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0009954; P:proximal/distal pattern formation; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR003893; Iroquois_homeo.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00548; IRO; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..482
FT                   /note="Iroquois-class homeodomain protein irx-5"
FT                   /id="PRO_0000388722"
FT   DNA_BIND        109..171
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          173..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..482
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  52905 MW;  7AACD176DA3FD7A6 CRC64;
     MSYPQGYLYQ PSASLALYSC PAYSTTVISG PRTDELGRSP SGSAFSPYAG STAFTASSAG
     FNSPLQYSGD PAAAFTSYVG SPYDHSAGMA GSLGYHPYAA PLGTYPYGDP AYRKNATRDA
     TATLKAWLNE HRKNPYPTKG EKIMLAIITK MTLTQVSTWF ANARRRLKKE NKMTWTPRNR
     SEDEEDDENI DLEKNEEDDP RKLEEKGDQD GDAGDQKRSP SAVDFDRLEG EVRQGKELDQ
     TRSDSEQNEV EERNDLLSKN SAPPTSPLCP PDQSPQAQED QNLHRHTVHN HHHQSIQQLH
     HHSHQSHPLD LVHRNALVQH GPVTNNATSV IHSPPASTSK PKLWSLAEIA TSSDKVKESS
     DAAAVAGTTP AQSMVVSASS PSRSPSAQCH FPSNTVLSRP LYYSNPFYPG YTNYGTFSHL
     HSHHGPSTTS PTVNSTHHFS GINQTVLNRA EALAKECKLR SQSQADLNKD TPYEMKKGMS
     SI