IRX6_HUMAN
ID IRX6_HUMAN Reviewed; 446 AA.
AC P78412; B2RN06; Q7Z2K0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Iroquois-class homeodomain protein IRX-6;
DE AltName: Full=Homeodomain protein IRXB3;
DE AltName: Full=Iroquois homeobox protein 6;
GN Name=IRX6; Synonyms=IRX7, IRXB3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA Hansen L., Wu Q., Tommerup N.;
RT "Characterization of the human homeobox two-cluster Iroquois gene family.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-195.
RA Lewis M.T., Strickland P.A., Ross S., Snyder C.J., Daniel C.W.;
RT "IRX: a new family of human homeobox genes from the breast.";
RL Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC P78412; Q03989: ARID5A; NbExp=3; IntAct=EBI-12100506, EBI-948603;
CC P78412; O43186: CRX; NbExp=3; IntAct=EBI-12100506, EBI-748171;
CC P78412; O76003: GLRX3; NbExp=5; IntAct=EBI-12100506, EBI-374781;
CC P78412; P49639: HOXA1; NbExp=3; IntAct=EBI-12100506, EBI-740785;
CC P78412; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-12100506, EBI-10241353;
CC P78412; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12100506, EBI-16439278;
CC P78412; P10916: MYL2; NbExp=3; IntAct=EBI-12100506, EBI-725770;
CC P78412; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-12100506, EBI-10271199;
CC P78412; Q99471: PFDN5; NbExp=3; IntAct=EBI-12100506, EBI-357275;
CC P78412; O60806: TBX19; NbExp=3; IntAct=EBI-12100506, EBI-12096770;
CC P78412; Q08117-2: TLE5; NbExp=5; IntAct=EBI-12100506, EBI-11741437;
CC P78412; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-12100506, EBI-492476;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000305}.
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DR EMBL; AY335937; AAQ16543.1; -; mRNA.
DR EMBL; AY335946; AAQ16552.1; -; Genomic_DNA.
DR EMBL; AK125053; BAC86033.1; -; mRNA.
DR EMBL; CH471092; EAW82823.1; -; Genomic_DNA.
DR EMBL; BC136573; AAI36574.1; -; mRNA.
DR EMBL; BC136576; AAI36577.1; -; mRNA.
DR EMBL; U90305; AAB50003.1; -; mRNA.
DR CCDS; CCDS32449.1; -.
DR RefSeq; NP_077311.2; NM_024335.2.
DR RefSeq; XP_005256194.1; XM_005256137.2.
DR AlphaFoldDB; P78412; -.
DR SMR; P78412; -.
DR BioGRID; 122602; 11.
DR IntAct; P78412; 12.
DR STRING; 9606.ENSP00000290552; -.
DR iPTMnet; P78412; -.
DR PhosphoSitePlus; P78412; -.
DR BioMuta; IRX6; -.
DR DMDM; 116242594; -.
DR jPOST; P78412; -.
DR MassIVE; P78412; -.
DR MaxQB; P78412; -.
DR PaxDb; P78412; -.
DR PeptideAtlas; P78412; -.
DR PRIDE; P78412; -.
DR Antibodypedia; 14626; 173 antibodies from 19 providers.
DR DNASU; 79190; -.
DR Ensembl; ENST00000290552.8; ENSP00000290552.8; ENSG00000159387.8.
DR GeneID; 79190; -.
DR KEGG; hsa:79190; -.
DR MANE-Select; ENST00000290552.8; ENSP00000290552.8; NM_024335.3; NP_077311.2.
DR UCSC; uc002ehy.4; human.
DR CTD; 79190; -.
DR DisGeNET; 79190; -.
DR GeneCards; IRX6; -.
DR HGNC; HGNC:14675; IRX6.
DR HPA; ENSG00000159387; Tissue enhanced (adipose tissue, heart muscle, skin).
DR MIM; 606196; gene.
DR neXtProt; NX_P78412; -.
DR OpenTargets; ENSG00000159387; -.
DR PharmGKB; PA29929; -.
DR VEuPathDB; HostDB:ENSG00000159387; -.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000159909; -.
DR HOGENOM; CLU_042927_1_0_1; -.
DR InParanoid; P78412; -.
DR OMA; EPAVQCQ; -.
DR OrthoDB; 814237at2759; -.
DR PhylomeDB; P78412; -.
DR TreeFam; TF319371; -.
DR PathwayCommons; P78412; -.
DR SignaLink; P78412; -.
DR BioGRID-ORCS; 79190; 27 hits in 1090 CRISPR screens.
DR ChiTaRS; IRX6; human.
DR GeneWiki; IRX6; -.
DR GenomeRNAi; 79190; -.
DR Pharos; P78412; Tbio.
DR PRO; PR:P78412; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; P78412; protein.
DR Bgee; ENSG00000159387; Expressed in apex of heart and 74 other tissues.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..446
FT /note="Iroquois-class homeodomain protein IRX-6"
FT /id="PRO_0000049162"
FT DNA_BIND 144..207
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 208..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..273
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 117
FT /note="S -> G (in Ref. 5; AAB50003)"
FT /evidence="ECO:0000305"
FT CONFLICT 444
FT /note="Missing (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 446 AA; 48240 MW; 4E542FEDD5D06912 CRC64;
MSFPHFGHPY RGASQFLASA SSSTTCCEST QRSVSDVASG STPAPALCCA PYDSRLLGSA
RPELGAALGI YGAPYAAAAA AQSYPGYLPY SPEPPSLYGA LNPQYEFKEA AGSFTSSLAQ
PGAYYPYERT LGQYQYERYG AVELSGAGRR KNATRETTST LKAWLNEHRK NPYPTKGEKI
MLAIITKMTL TQVSTWFANA RRRLKKENKM TWAPKNKGGE ERKAEGGEED SLGCLTADTK
EVTASQEARG LRLSDLEDLE EEEEEEEEAE DEEVVATAGD RLTEFRKGAQ SLPGPCAAAR
EGRLERRECG LAAPRFSFND PSGSEEADFL SAETGSPRLT MHYPCLEKPR IWSLAHTATA
SAVEGAPPAR PRPRSPECRM IPGQPPASAR RLSVPRDSAC DESSCIPKAF GNPKFALQGL
PLNCAPCPRR SEPVVQCQYP SGAEAG
