IRX6_MOUSE
ID IRX6_MOUSE Reviewed; 438 AA.
AC Q9ER75; A1L3D2; E9Q2V2;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Iroquois-class homeodomain protein IRX-6;
DE AltName: Full=Homeodomain protein IRXB3;
DE AltName: Full=Iroquois homeobox protein 6;
GN Name=Irx6; Synonyms=Irxb3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NIH Swiss; TISSUE=Heart;
RX PubMed=11042145; DOI=10.1101/gr.144100;
RA Peters T., Dildrop R., Ausmeier K., Ruether U.;
RT "Organization of mouse Iroquois homeobox genes in two clusters suggests a
RT conserved regulation and function in vertebrate development.";
RL Genome Res. 10:1453-1462(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000305}.
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DR EMBL; AJ271055; CAC10403.1; -; mRNA.
DR EMBL; AC134337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC130029; AAI30030.1; -; mRNA.
DR CCDS; CCDS80913.1; -.
DR RefSeq; NP_001288066.1; NM_001301137.1.
DR AlphaFoldDB; Q9ER75; -.
DR SMR; Q9ER75; -.
DR BioGRID; 211066; 3.
DR IntAct; Q9ER75; 1.
DR STRING; 10090.ENSMUSP00000034185; -.
DR PhosphoSitePlus; Q9ER75; -.
DR PaxDb; Q9ER75; -.
DR PRIDE; Q9ER75; -.
DR ProteomicsDB; 301673; -.
DR Antibodypedia; 14626; 173 antibodies from 19 providers.
DR DNASU; 64379; -.
DR Ensembl; ENSMUST00000167261; ENSMUSP00000127446; ENSMUSG00000031738.
DR GeneID; 64379; -.
DR KEGG; mmu:64379; -.
DR UCSC; uc009muc.2; mouse.
DR CTD; 79190; -.
DR MGI; MGI:1927642; Irx6.
DR VEuPathDB; HostDB:ENSMUSG00000031738; -.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000159909; -.
DR HOGENOM; CLU_042927_1_0_1; -.
DR InParanoid; Q9ER75; -.
DR BioGRID-ORCS; 64379; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q9ER75; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9ER75; protein.
DR Bgee; ENSMUSG00000031738; Expressed in endocardium of ventricle and 39 other tissues.
DR ExpressionAtlas; Q9ER75; baseline and differential.
DR Genevisible; Q9ER75; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IBA:GO_Central.
DR GO; GO:0009584; P:detection of visible light; IMP:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010842; P:retina layer formation; IMP:MGI.
DR GO; GO:0060040; P:retinal bipolar neuron differentiation; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR InterPro; IPR003893; Iroquois_homeo.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00548; IRO; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..438
FT /note="Iroquois-class homeodomain protein IRX-6"
FT /id="PRO_0000049163"
FT DNA_BIND 141..204
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 205..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..267
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 33
FT /note="P -> S (in Ref. 1; CAC10403 and 3; AAI30030)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="R -> G (in Ref. 1; CAC10403 and 3; AAI30030)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 438 AA; 47352 MW; 51E5421FB653A0F0 CRC64;
MAFSPFGHPY GSTSQFLVSA SSSATCCETA PRPVSDVASA STSASTLCCT PYDSRLLGSA
RPELGAALGI YGAPYAAAQS YPGYLTYGPE PPTLCGALNP QYEFKDAAGS FAPSLTQPGA
YYPYETTLGQ YQYDRYGGVE LSSAGRRKNA TRESTSALKA WLHEHRKNPY PTKGEKIMLA
IITKMTLTQV STWFANARRR LKKENKMTWA PKNKGGEERK ADSGEDSLGC LNGDTKDATA
SQEARGLRLS DLEDLEEEEE EEEAEEEAAV SAARRLADFQ KSTQPLPAPC AAAQERCLES
RECGLGLPRF SFTEAPQSGE ADFITAEPGG PTMILHYPSG HKPRIWSLAH TAAASAVESA
PSTPPRAQSP ECHMIPRQPS SIRRLLVPRD SEGEEDSPAA KAFGNSTFTL QGLPLNCAPY
PRRREPEVRF QYPSGAEG
