ID   IRX_CAEEL               Reviewed;         377 AA.
AC   Q93348; B0M0N5;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 3.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Putative iroquois-class homeodomain protein irx-1;
GN   Name=irx-1; ORFNames=C36F7.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000305}.
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DR   EMBL; Z81045; CAB02816.2; -; Genomic_DNA.
DR   EMBL; Z81048; CAB02816.2; JOINED; Genomic_DNA.
DR   PIR; T19792; T19792.
DR   RefSeq; NP_492533.2; NM_060132.4.
DR   AlphaFoldDB; Q93348; -.
DR   SMR; Q93348; -.
DR   BioGRID; 38215; 15.
DR   IntAct; Q93348; 14.
DR   STRING; 6239.C36F7.1; -.
DR   iPTMnet; Q93348; -.
DR   EPD; Q93348; -.
DR   PaxDb; Q93348; -.
DR   PeptideAtlas; Q93348; -.
DR   EnsemblMetazoa; C36F7.1.1; C36F7.1.1; WBGene00007984.
DR   GeneID; 172789; -.
DR   KEGG; cel:CELE_C36F7.1; -.
DR   UCSC; C36F7.1; c. elegans.
DR   CTD; 172789; -.
DR   WormBase; C36F7.1; CE42075; WBGene00007984; irx-1.
DR   eggNOG; KOG0773; Eukaryota.
DR   GeneTree; ENSGT00940000165426; -.
DR   HOGENOM; CLU_708287_0_0_1; -.
DR   InParanoid; Q93348; -.
DR   OMA; HRLYHPY; -.
DR   OrthoDB; 1318473at2759; -.
DR   SignaLink; Q93348; -.
DR   PRO; PR:Q93348; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00007984; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048468; P:cell development; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   InterPro; IPR003893; Iroquois_homeo.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SMART; SM00548; IRO; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..377
FT                   /note="Putative iroquois-class homeodomain protein irx-1"
FT                   /id="PRO_0000049164"
FT   DNA_BIND        115..177
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          176..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        176..190
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..284
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   377 AA;  40784 MW;  EE514BFAABEFAD34 CRC64;
     MIPIANQVKM EEPTTPQTTT PAPPTSAPDA LRGILPPNLL GQFHFHPAMA QVLAAQAQAA
     AAAQQATLAG FPGVPMFPHG IPADLKPEML LGGGPGPMPM FFSDAHRLYH PYGLDGIKKR
     NATREATAPL KDWLHSHRKN PYPSKADKVM LAVGTGMTLT QVSTWFANAR RRLKKENKMT
     WSPQNRRGDG CDDDEDDDDD DMNRPSSSTS INSERKGESL FGKPHLASPT PSGGSGGSDE
     LTTPKKELVS PIPNDDSESP KRKPKMWSIA DVTSDDDSSK KDSPPSSDEN LLTGSLFQNA
     MKKQMEVMAR LDPTLFRHTM HPFMFQLLAQ QAAQGQQLAL LAPQTTPPNE AGLNSQAETS
     TPSPASSPTS SPRSHQE