APRR7_ARATH
ID APRR7_ARATH Reviewed; 727 AA.
AC Q93WK5; Q9LZ04;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 130.
DE RecName: Full=Two-component response regulator-like APRR7;
DE AltName: Full=Pseudo-response regulator 7;
GN Name=APRR7; OrderedLocusNames=At5g02810; ORFNames=F9G14_120;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=11100772; DOI=10.1093/pcp/pcd043;
RA Matsushika A., Makino S., Kojima M., Mizuno T.;
RT "Circadian waves of expression of the APRR1/TOC1 family of pseudo-response
RT regulators in Arabidopsis thaliana: insight into the plant circadian
RT clock.";
RL Plant Cell Physiol. 41:1002-1012(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=10945350; DOI=10.1093/pcp/41.6.791;
RA Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T.,
RA Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.;
RT "Genes encoding pseudo-response regulators: insight into His-to-Asp
RT phosphorelay and circadian rhythm in Arabidopsis thaliana.";
RL Plant Cell Physiol. 41:791-803(2000).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=14563930; DOI=10.1105/tpc.015065;
RA Kaczorowski K.A., Quail P.H.;
RT "Arabidopsis PSEUDO-RESPONSE REGULATOR 7 is a signaling intermediate in
RT phytochrome-regulated seedling deetiolation and phasing of the circadian
RT clock.";
RL Plant Cell 15:2654-2665(2003).
RN [7]
RP PHOSPHORYLATION.
RX PubMed=18562312; DOI=10.1074/jbc.m803471200;
RA Fujiwara S., Wang L., Han L., Suh S.-S., Salome P.A., McClung C.R.,
RA Somers D.E.;
RT "Post-translational regulation of the Arabidopsis circadian clock through
RT selective proteolysis and phosphorylation of pseudo-response regulator
RT proteins.";
RL J. Biol. Chem. 283:23073-23083(2008).
RN [8]
RP FUNCTION.
RX PubMed=20233950; DOI=10.1105/tpc.109.072892;
RA Nakamichi N., Kiba T., Henriques R., Mizuno T., Chua N.H., Sakakibara H.;
RT "PSEUDO-RESPONSE REGULATORS 9, 7, and 5 are transcriptional repressors in
RT the Arabidopsis circadian clock.";
RL Plant Cell 22:594-605(2010).
RN [9]
RP FUNCTION.
RX PubMed=21098730; DOI=10.1105/tpc.110.079087;
RA Salome P.A., Weigel D., McClung C.R.;
RT "The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and
RT PRR9 in temperature compensation.";
RL Plant Cell 22:3650-3661(2010).
RN [10]
RP FUNCTION.
RX PubMed=21357491; DOI=10.1105/tpc.110.081661;
RA Wang Y., Wu J.F., Nakamichi N., Sakakibara H., Nam H.G., Wu S.H.;
RT "LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive
RT feedback regulatory loop in the Arabidopsis circadian clock.";
RL Plant Cell 23:486-498(2011).
RN [11]
RP REGULATION.
RX PubMed=22942380; DOI=10.1105/tpc.112.100081;
RA Wang X., Wu F., Xie Q., Wang H., Wang Y., Yue Y., Gahura O., Ma S., Liu L.,
RA Cao Y., Jiao Y., Puta F., McClung C.R., Xu X., Ma L.;
RT "SKIP is a component of the spliceosome linking alternative splicing and
RT the circadian clock in Arabidopsis.";
RL Plant Cell 24:3278-3295(2012).
RN [12]
RP FUNCTION.
RX PubMed=23027938; DOI=10.1073/pnas.1205156109;
RA Nakamichi N., Kiba T., Kamioka M., Suzuki T., Yamashino T., Higashiyama T.,
RA Sakakibara H., Mizuno T.;
RT "Transcriptional repressor PRR5 directly regulates clock-output pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:17123-17128(2012).
RN [13]
RP INDUCTION BY HEAT-SHOCK.
RX PubMed=23933882; DOI=10.1105/tpc.113.114306;
RA Karayekov E., Sellaro R., Legris M., Yanovsky M.J., Casal J.J.;
RT "Heat shock-induced fluctuations in clock and light signaling enhance
RT phytochrome B-mediated Arabidopsis deetiolation.";
RL Plant Cell 25:2892-2906(2013).
RN [14]
RP FUNCTION.
RX PubMed=23808423; DOI=10.1111/tpj.12276;
RA Liu T., Carlsson J., Takeuchi T., Newton L., Farre E.M.;
RT "Direct regulation of abiotic responses by the Arabidopsis circadian clock
RT component PRR7.";
RL Plant J. 76:101-114(2013).
RN [15]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION BY LIGHT AND SUCROSE.
RX PubMed=24153186; DOI=10.1038/nature12603;
RA Haydon M.J., Mielczarek O., Robertson F.C., Hubbard K.E., Webb A.A.;
RT "Photosynthetic entrainment of the Arabidopsis thaliana circadian clock.";
RL Nature 502:689-692(2013).
CC -!- FUNCTION: Transcriptional repressor of CCA1 and LHY, and positive
CC regulator of LWD1 and LWD2 expression. Represses the expression of
CC other clock proteins and master regulators of plant growth, development
CC and response to abiotic stress. Involved in the positive and negative
CC feedback loops of the circadian clock. Controls photoperiodic flowering
CC response and temperature compensation. Expression of several members of
CC the ARR-like family is controlled by circadian rhythm. APRR9, APRR7,
CC and APRR5 coordinately act on the upstream region of the target genes
CC to repress their expression from noon until midnight. The particular
CC coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and
CC APPR1 result to circadian waves that may be at the basis of the
CC endogenous circadian clock. {ECO:0000269|PubMed:11100772,
CC ECO:0000269|PubMed:14563930, ECO:0000269|PubMed:20233950,
CC ECO:0000269|PubMed:21098730, ECO:0000269|PubMed:21357491,
CC ECO:0000269|PubMed:23027938, ECO:0000269|PubMed:23808423,
CC ECO:0000269|PubMed:24153186}.
CC -!- INTERACTION:
CC Q93WK5; Q9FGM1: PYL8; NbExp=3; IntAct=EBI-25528701, EBI-2429535;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00357,
CC ECO:0000269|PubMed:14563930}.
CC -!- INDUCTION: Up-regulated by heat-shock and light at dawn, and down-
CC regulated by the sugars produced by photosynthesis.
CC {ECO:0000269|PubMed:23933882, ECO:0000269|PubMed:24153186}.
CC -!- PTM: Phosphorylated. Phosphorylation varies throughout the diurnal
CC cycle. {ECO:0000269|PubMed:18562312}.
CC -!- DISRUPTION PHENOTYPE: Insensitive to the effect of sucrose on the
CC circadian period. {ECO:0000269|PubMed:24153186}.
CC -!- MISCELLANEOUS: Regulated at the level of mRNA maturation and
CC alternative splicing by SKIP (PubMed:22942380). The expression of
CC APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2,
CC indicating the existence of a positive feedback loop within the
CC circadian clock (PubMed:21357491). {ECO:0000305|PubMed:21357491,
CC ECO:0000305|PubMed:22942380}.
CC -!- SIMILARITY: Belongs to the ARR-like family. {ECO:0000305}.
CC -!- CAUTION: Lacks the phospho-accepting Asp (here Glu-130), present in the
CC receiver domain, which is one of the conserved features of two-
CC component response regulators (ARRs) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86035.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB046954; BAB13742.1; -; mRNA.
DR EMBL; AL162973; CAB86035.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90520.1; -; Genomic_DNA.
DR EMBL; AY039943; AAK64047.1; -; mRNA.
DR EMBL; AY142560; AAN13129.1; -; mRNA.
DR PIR; T48302; T48302.
DR RefSeq; NP_568107.1; NM_120359.3.
DR AlphaFoldDB; Q93WK5; -.
DR SMR; Q93WK5; -.
DR BioGRID; 17069; 11.
DR IntAct; Q93WK5; 1.
DR STRING; 3702.AT5G02810.1; -.
DR iPTMnet; Q93WK5; -.
DR PaxDb; Q93WK5; -.
DR PRIDE; Q93WK5; -.
DR ProteomicsDB; 244462; -.
DR EnsemblPlants; AT5G02810.1; AT5G02810.1; AT5G02810.
DR GeneID; 831793; -.
DR Gramene; AT5G02810.1; AT5G02810.1; AT5G02810.
DR KEGG; ath:AT5G02810; -.
DR Araport; AT5G02810; -.
DR TAIR; locus:2151206; AT5G02810.
DR eggNOG; KOG1601; Eukaryota.
DR HOGENOM; CLU_015512_1_0_1; -.
DR InParanoid; Q93WK5; -.
DR OMA; PPNQCSN; -.
DR OrthoDB; 320146at2759; -.
DR PhylomeDB; Q93WK5; -.
DR PRO; PR:Q93WK5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q93WK5; baseline and differential.
DR Genevisible; Q93WK5; AT.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; IPI:TAIR.
DR GO; GO:0007623; P:circadian rhythm; IMP:TAIR.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0010017; P:red or far-red light signaling pathway; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR010402; CCT_domain.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 2.
DR Pfam; PF06203; CCT; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS51017; CCT; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Biological rhythms; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..727
FT /note="Two-component response regulator-like APRR7"
FT /id="PRO_0000081439"
FT DOMAIN 79..197
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 669..711
FT /note="CCT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00357"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 339..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 727 AA; 79663 MW; 13057E6AE6E50C00 CRC64;
MNANEEGEGS RYPITDRKTG ETKFDRVESR TEKHSEEEKT NGITMDVRNG SSGGLQIPLS
QQTAATVCWE RFLHVRTIRV LLVENDDCTR YIVTALLRNC SYEVVEASNG IQAWKVLEDL
NNHIDIVLTE VIMPYLSGIG LLCKILNHKS RRNIPVIMMS SHDSMGLVFK CLSKGAVDFL
VKPIRKNELK ILWQHVWRRC QSSSGSGSES GTHQTQKSVK SKSIKKSDQD SGSSDENENG
SIGLNASDGS SDGSGAQSSW TKKAVDVDDS PRAVSLWDRV DSTCAQVVHS NPEFPSNQLV
APPAEKETQE HDDKFEDVTM GRDLEISIRR NCDLALEPKD EPLSKTTGIM RQDNSFEKSS
SKWKMKVGKG PLDLSSESPS SKQMHEDGGS SFKAMSSHLQ DNREPEAPNT HLKTLDTNEA
SVKISEELMH VEHSSKRHRG TKDDGTLVRD DRNVLRRSEG SAFSRYNPAS NANKISGGNL
GSTSLQDNNS QDLIKKTEAA YDCHSNMNES LPHNHRSHVG SNNFDMSSTT ENNAFTKPGA
PKVSSAGSSS VKHSSFQPLP CDHHNNHASY NLVHVAERKK LPPQCGSSNV YNETIEGNNN
TVNYSVNGSV SGSGHGSNGP YGSSNGMNAG GMNMGSDNGA GKNGNGDGSG SGSGSGSGNL
ADENKISQRE AALTKFRQKR KERCFRKKVR YQSRKKLAEQ RPRVRGQFVR KTAAATDDND
IKNIEDS
