APRR8_ARATH
ID APRR8_ARATH Reviewed; 367 AA.
AC O23100; Q0WP57;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2004, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Putative two-component response regulator-like APRR8;
DE AltName: Full=Pseudo-response regulator 8;
GN Name=APRR8; OrderedLocusNames=At4g00760; ORFNames=A_TM018A10.20, T18A10.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RX PubMed=10945350; DOI=10.1093/pcp/41.6.791;
RA Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T.,
RA Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.;
RT "Genes encoding pseudo-response regulators: insight into His-to-Asp
RT phosphorelay and circadian rhythm in Arabidopsis thaliana.";
RL Plant Cell Physiol. 41:791-803(2000).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O23100-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O23100-2; Sequence=VSP_040641;
CC -!- SIMILARITY: Belongs to the ARR-like family. {ECO:0000305}.
CC -!- CAUTION: Lacks the phospho-accepting Asp (here Glu-66), present in the
CC receiver domain, which is one of the conserved features of two-
CC component response regulators (ARRs) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB62863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80885.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF013294; AAB62863.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161472; CAB80885.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE81933.1; -; Genomic_DNA.
DR EMBL; AK229225; BAF01092.1; -; mRNA.
DR PIR; T01570; T01570.
DR RefSeq; NP_191985.3; NM_116302.4. [O23100-2]
DR AlphaFoldDB; O23100; -.
DR SMR; O23100; -.
DR PaxDb; O23100; -.
DR PRIDE; O23100; -.
DR EnsemblPlants; AT4G00760.1; AT4G00760.1; AT4G00760. [O23100-2]
DR GeneID; 828011; -.
DR Gramene; AT4G00760.1; AT4G00760.1; AT4G00760. [O23100-2]
DR KEGG; ath:AT4G00760; -.
DR Araport; AT4G00760; -.
DR TAIR; locus:2134548; AT4G00760.
DR eggNOG; ENOG502RRI7; Eukaryota.
DR HOGENOM; CLU_750874_0_0_1; -.
DR OMA; FRLIEMN; -.
DR OrthoDB; 1336037at2759; -.
DR PhylomeDB; O23100; -.
DR PRO; PR:O23100; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O23100; baseline and differential.
DR Genevisible; O23100; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR045279; ARR-like.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43874; PTHR43874; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..367
FT /note="Putative two-component response regulator-like
FT APRR8"
FT /id="PRO_0000081440"
FT DOMAIN 15..129
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT REGION 158..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 158..192
FT /evidence="ECO:0000255"
FT COMPBIAS 165..213
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..31
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_040641"
SQ SEQUENCE 367 AA; 41295 MW; FCA26FFE5E365BFE CRC64;
MENTEETERF SNDICVLLLD SDATCLANLS EMIRKCGYKV VATTRADDLP LIINNKDKKI
DLVLAEFRLI EMNKYELLEK IRSICEIPVV VSGAHVKDAI VECLCRGAKL CLEKPLMEND
FKILWQFTVS RQRNFRSQID INPPEKNHSI THTQSLGAEL KKNNNNSEVE TEDLDKYKDE
LGQGNKRKER ADTDTGEHTE KNNGSDLGDQ KKPKLLFADD LQNETLEAVP NIEEANNERK
APTEIKKNGE SSEKKSPELV CMEEELQKWS AESFIDLTAS VENESQDPLE SVGDSVGPHE
IPLSPPESSN NNVAAQLQMP THEALDEEVM QDGLSLSDLE VDLQEGHGSN KELFDKIFTD
LAKELKP
