ID   ISAA_STAES              Reviewed;         235 AA.
AC   Q8CMZ9;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Probable transglycosylase IsaA;
DE            EC=3.2.-.-;
DE   AltName: Full=Immunodominant staphylococcal antigen A;
DE   Flags: Precursor;
GN   Name=isaA; OrderedLocusNames=SE_2126;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Is able to cleave peptidoglycan. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. IsaA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE015929; AAO05768.1; -; Genomic_DNA.
DR   RefSeq; NP_765681.1; NC_004461.1.
DR   RefSeq; WP_002438072.1; NZ_WBME01000013.1.
DR   AlphaFoldDB; Q8CMZ9; -.
DR   STRING; 176280.SE_2126; -.
DR   EnsemblBacteria; AAO05768; AAO05768; SE_2126.
DR   GeneID; 50017793; -.
DR   KEGG; sep:SE_2126; -.
DR   PATRIC; fig|176280.10.peg.2076; -.
DR   eggNOG; COG0741; Bacteria.
DR   HOGENOM; CLU_099865_0_0_9; -.
DR   OMA; MWNTIVM; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR010618; RPF.
DR   Pfam; PF06737; Transglycosylas; 1.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..235
FT                   /note="Probable transglycosylase IsaA"
FT                   /id="PRO_0000021532"
FT   REGION          95..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   235 AA;  24547 MW;  78DFD55EB4BC9923 CRC64;
     MKKTVIASTL AVSLGIAGYG LSGHEAHASE TTNVDKAHLV DLAQHNPEEL NAKPVQAGAY
     DIHFVDNGYQ YNFTSNGSEW SWSYAVAGSD ADYTESSSNQ EVSANTQSSN TNVQAVSAPT
     SSESRSYSTS TTSYSAPSHN YSSHSSSVRL SNGNTAGSVG SYAAAQMAAR TGVSASTWEH
     IIARESNGQL HARNASGAAG LFQTMPGWGS TGSVNDQINA AYKAYKAQGL SAWGM