ID   ISAA_STAHJ              Reviewed;         238 AA.
AC   Q4L980;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Probable transglycosylase IsaA;
DE            EC=3.2.-.-;
DE   AltName: Full=Immunodominant staphylococcal antigen A;
DE   Flags: Precursor;
GN   Name=isaA; OrderedLocusNames=SH0486;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Is able to cleave peptidoglycan. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. IsaA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AP006716; BAE03795.1; -; Genomic_DNA.
DR   RefSeq; WP_011274811.1; NC_007168.1.
DR   AlphaFoldDB; Q4L980; -.
DR   STRING; 279808.SH0486; -.
DR   EnsemblBacteria; BAE03795; BAE03795; SH0486.
DR   KEGG; sha:SH0486; -.
DR   eggNOG; COG0741; Bacteria.
DR   HOGENOM; CLU_099865_0_0_9; -.
DR   OMA; MWNTIVM; -.
DR   OrthoDB; 1574792at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..238
FT                   /note="Probable transglycosylase IsaA"
FT                   /id="PRO_0000272659"
FT   REGION          115..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  24699 MW;  508F676BD03240E3 CRC64;
     MKKTVIASSL AVALGVTGYA LTTDNSAHAS ESTTNYAQLA NLAQNNPSEL NAHPVQAGAY
     NITFVKDGFK YNFTSDGQSW SWNYTYVGGA DTVATTQAAP AAQSTDYSAS YSNEASTQSV
     SSNQQSSNTN VEAVSAPKTT SYSASTSSSS SASTGGSVKE QFLANGGTEA AWNAIVMPES
     GGNPNAVNPA GYRGLGQTKE SWGTGSVASQ TKGMINYANS RYGSLDAAIA FRDNHGWW