ID   ISAA_STAXY              Reviewed;         243 AA.
AC   A7IY64;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Probable transglycosylase IsaA;
DE            EC=3.2.-.-;
DE   AltName: Full=Immunodominant staphylococcal antigen A;
DE   Flags: Precursor;
GN   Name=isaA;
OS   Staphylococcus xylosus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1288;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 20267 / Isolate C2A;
RA   Planchon S., Talon R., Leroy S.;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=DSM 20267 / Isolate C2A;
RX   PubMed=17636987; DOI=10.1021/pr070139+;
RA   Planchon S., Chambon C., Desvaux M., Chafsey I., Leroy S., Talon R.,
RA   Hebraud M.;
RT   "Proteomic analysis of cell envelope from Staphylococcus xylosus C2a, a
RT   coagulase-negative staphylococcus.";
RL   J. Proteome Res. 6:3566-3580(2007).
CC   -!- FUNCTION: Is able to cleave peptidoglycan. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transglycosylase family. IsaA subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ498895; ABF47259.1; -; Genomic_DNA.
DR   RefSeq; WP_047171833.1; NZ_QXUB01000005.1.
DR   AlphaFoldDB; A7IY64; -.
DR   STRING; 1288.SXYLSMQ121_0319; -.
DR   KEGG; sxo:SXYL_00323; -.
DR   eggNOG; COG1388; Bacteria.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   1: Evidence at protein level;
KW   Glycosidase; Hydrolase; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..243
FT                   /note="Probable transglycosylase IsaA"
FT                   /id="PRO_0000329003"
FT   REGION          99..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   243 AA;  25379 MW;  AAC630EC41EAB5D9 CRC64;
     MKKTILASSL AVALGVTGYA TTADHNQAHA SEENIDKAHL ADLAQNNPEE LNQKPLHAGA
     YNYNFVLGGN EYTFTSNGQS WSWNYTAAGA QSATSNSVQD VTTQATTNTN ETSASEVSAQ
     KQSSNTPVAA VEAPKASSNT QTSAATRTYK VAQTSAASTG GSVKAQFLAA GGTEAMWNSI
     VMPESSGNPN AVNPAGYRGL GQTKESWGSG SVASQTKGMI NYGESRYGSM EAAMTFRASH
     GWW