ID   ISAB_STAA8              Reviewed;         175 AA.
AC   Q2FUX3;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Immunodominant staphylococcal antigen B;
DE   Flags: Precursor;
GN   Name=isaB; OrderedLocusNames=SAOUHSC_02972;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   INDUCTION.
RX   PubMed=15870358; DOI=10.1128/aem.71.5.2663-2676.2005;
RA   Resch A., Rosenstein R., Nerz C., Goetz F.;
RT   "Differential gene expression profiling of Staphylococcus aureus cultivated
RT   under biofilm and planktonic conditions.";
RL   Appl. Environ. Microbiol. 71:2663-2676(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- INDUCTION: Increased expression in vivo during human sepsis. Highly
CC       expressed under biofilm conditions after 24 hours of growth.
CC       {ECO:0000269|PubMed:15870358}.
CC   -!- SIMILARITY: Belongs to the IsaB family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD31961.1; -; Genomic_DNA.
DR   RefSeq; WP_001044560.1; NZ_LS483365.1.
DR   RefSeq; YP_501423.1; NC_007795.1.
DR   AlphaFoldDB; Q2FUX3; -.
DR   SMR; Q2FUX3; -.
DR   STRING; 93061.SAOUHSC_02972; -.
DR   EnsemblBacteria; ABD31961; ABD31961; SAOUHSC_02972.
DR   GeneID; 3921673; -.
DR   KEGG; sao:SAOUHSC_02972; -.
DR   PATRIC; fig|93061.5.peg.2681; -.
DR   HOGENOM; CLU_119552_0_0_9; -.
DR   OMA; WYKYNGY; -.
DR   PRO; PR:Q2FUX3; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000250"
FT   CHAIN           37..175
FT                   /note="Immunodominant staphylococcal antigen B"
FT                   /id="PRO_0000272663"
SQ   SEQUENCE   175 AA;  19370 MW;  D8C994A216EF3BB3 CRC64;
     MNKTSKVCVA ATLALGTLIG VTVVENSAPT SKQAQAAITP YYTYNGYIGN NANFILDKNF
     INAIKYDNVK FNGIKLAKTN TIKKVEKYDQ TFKGVSAKGN EASQLQFVVK NNISLKDIQK
     AYGKDLKKEN GKTKEADSGI FYYQNAKKTL GIWFVVDHNR VVEVTVGHTP YKTSK