ID   ISAB_STAAS              Reviewed;         175 AA.
AC   Q6G636;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Immunodominant staphylococcal antigen B;
DE   Flags: Precursor;
GN   Name=isaB; OrderedLocusNames=SAS2524;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IsaB family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG44341.1; -; Genomic_DNA.
DR   RefSeq; WP_001044560.1; NC_002953.3.
DR   AlphaFoldDB; Q6G636; -.
DR   SMR; Q6G636; -.
DR   KEGG; sas:SAS2524; -.
DR   HOGENOM; CLU_119552_0_0_9; -.
DR   OMA; WYKYNGY; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Secreted; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000250"
FT   CHAIN           37..175
FT                   /note="Immunodominant staphylococcal antigen B"
FT                   /id="PRO_0000272669"
SQ   SEQUENCE   175 AA;  19370 MW;  D8C994A216EF3BB3 CRC64;
     MNKTSKVCVA ATLALGTLIG VTVVENSAPT SKQAQAAITP YYTYNGYIGN NANFILDKNF
     INAIKYDNVK FNGIKLAKTN TIKKVEKYDQ TFKGVSAKGN EASQLQFVVK NNISLKDIQK
     AYGKDLKKEN GKTKEADSGI FYYQNAKKTL GIWFVVDHNR VVEVTVGHTP YKTSK