ID   ISAB_STAAU              Reviewed;         175 AA.
AC   Q9LAB5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Immunodominant staphylococcal antigen B;
DE   Flags: Precursor;
GN   Name=isaB;
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 37-66, SUBCELLULAR
RP   LOCATION, AND INDUCTION.
RC   STRAIN=M804;
RX   PubMed=11024354; DOI=10.1111/j.1574-695x.2000.tb01517.x;
RA   Lorenz U., Ohlsen K., Karch H., Hecker M., Thiede A., Hacker J.;
RT   "Human antibody response during sepsis against targets expressed by
RT   methicillin resistant Staphylococcus aureus.";
RL   FEMS Immunol. Med. Microbiol. 29:145-153(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11024354}.
CC   -!- INDUCTION: Increased expression in vivo during human sepsis. Highly
CC       expressed under biofilm conditions after 24 hours of growth.
CC       {ECO:0000269|PubMed:11024354}.
CC   -!- SIMILARITY: Belongs to the IsaB family. {ECO:0000305}.
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DR   EMBL; AF144682; AAF66692.1; -; Genomic_DNA.
DR   RefSeq; WP_001044560.1; NZ_WYDB01000001.1.
DR   AlphaFoldDB; Q9LAB5; -.
DR   SMR; Q9LAB5; -.
DR   OMA; WYKYNGY; -.
DR   PHI-base; PHI:6865; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000269|PubMed:11024354"
FT   CHAIN           37..175
FT                   /note="Immunodominant staphylococcal antigen B"
FT                   /id="PRO_0000272661"
SQ   SEQUENCE   175 AA;  19370 MW;  D8C994A216EF3BB3 CRC64;
     MNKTSKVCVA ATLALGTLIG VTVVENSAPT SKQAQAAITP YYTYNGYIGN NANFILDKNF
     INAIKYDNVK FNGIKLAKTN TIKKVEKYDQ TFKGVSAKGN EASQLQFVVK NNISLKDIQK
     AYGKDLKKEN GKTKEADSGI FYYQNAKKTL GIWFVVDHNR VVEVTVGHTP YKTSK