ID   ISC10_YEAST             Reviewed;         267 AA.
AC   P32645; D3DM89;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Meiosis-specific protein ISC10;
GN   Name=ISC10; OrderedLocusNames=YER180C; ORFNames=SYGP-ORF62;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SK1;
RX   PubMed=8455558; DOI=10.1007/bf00282804;
RA   Kobayashi T., Hotta Y., Tabata S.;
RT   "Isolation and characterization of a yeast gene that is homologous with a
RT   meiosis-specific cDNA from a plant.";
RL   Mol. Gen. Genet. 237:225-232(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
CC   -!- FUNCTION: Indispensable for spore formation.
CC   -!- DEVELOPMENTAL STAGE: Expressed 7.5 hours after induction of meiosis.
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DR   EMBL; D10865; BAA01638.1; -; Genomic_DNA.
DR   EMBL; U18922; AAB64707.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07843.1; -; Genomic_DNA.
DR   PIR; S30277; S30277.
DR   RefSeq; NP_011107.1; NM_001179070.1.
DR   AlphaFoldDB; P32645; -.
DR   BioGRID; 36933; 75.
DR   DIP; DIP-1397N; -.
DR   IntAct; P32645; 4.
DR   MINT; P32645; -.
DR   STRING; 4932.YER180C; -.
DR   PaxDb; P32645; -.
DR   PRIDE; P32645; -.
DR   EnsemblFungi; YER180C_mRNA; YER180C; YER180C.
DR   GeneID; 856927; -.
DR   KEGG; sce:YER180C; -.
DR   SGD; S000000982; ISC10.
DR   VEuPathDB; FungiDB:YER180C; -.
DR   eggNOG; ENOG502S87G; Eukaryota.
DR   HOGENOM; CLU_089051_0_0_1; -.
DR   InParanoid; P32645; -.
DR   OMA; XITDEIA; -.
DR   BioCyc; YEAST:G3O-30338-MON; -.
DR   PRO; PR:P32645; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P32645; protein.
DR   GO; GO:0030437; P:ascospore formation; IMP:SGD.
PE   2: Evidence at transcript level;
KW   Cell cycle; Meiosis; Reference proteome; Sporulation.
FT   CHAIN           1..267
FT                   /note="Meiosis-specific protein ISC10"
FT                   /id="PRO_0000084242"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   267 AA;  31655 MW;  669B56B20EC7924C CRC64;
     MDVDERLHQD ENQTHPFSQK KSSSFLIKEK AATKSKDLEH IRLRDLNFNH RKKLDDKKLA
     KQIPVKANFK KPNEIEARAN LNSNELTDIN LDYIPDSPSI EKISGPEDSI VVTPRNIIHL
     QSDSDIILEE CEHNYDCSPF YRLFNYENRI EPDDYEAIIN AIITDEIAGT YPVFERELEY
     QELKSLVRKR DYIMYYFLSR DYRGFFQLKE ERTLFYRYPS IAYTSPLRYL DNGSETEQFT
     GDDDEELQSF DFENTSSVRT LDSNIWR