ID   ISC2B_MOUSE             Reviewed;         210 AA.
AC   Q9DCC7; Q80V19;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Isochorismatase domain-containing protein 2B;
GN   Name=Isoc2b; Synonyms=Isoc2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Kidney;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Brain, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=17658461; DOI=10.1016/j.bbrc.2007.06.181;
RA   Huang X., Shi Z., Wang W., Bai J., Chen Z., Xu J., Zhang D., Fu S.;
RT   "Identification and characterization of a novel protein ISOC2 that
RT   interacts with p16INK4a.";
RL   Biochem. Biophys. Res. Commun. 361:287-293(2007).
RN   [4]
RP   SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-178, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA   Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA   Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT   "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT   pathways.";
RL   Mol. Cell 50:919-930(2013).
CC   -!- SUBUNIT: Interacts with CDKN2A. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Localizes to the nucleus in the presence of CDKN2A. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ubiquitous. Expressed predominantly in uterus,
CC       stomach and urinary tract. {ECO:0000269|PubMed:17658461}.
CC   -!- SIMILARITY: Belongs to the isochorismatase family. {ECO:0000305}.
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DR   EMBL; AK002905; BAB22446.1; -; mRNA.
DR   EMBL; BC046756; AAH46756.1; -; mRNA.
DR   EMBL; BC049278; AAH49278.1; -; mRNA.
DR   CCDS; CCDS20748.1; -.
DR   RefSeq; NP_080434.1; NM_026158.2.
DR   AlphaFoldDB; Q9DCC7; -.
DR   SMR; Q9DCC7; -.
DR   STRING; 10090.ENSMUSP00000066859; -.
DR   iPTMnet; Q9DCC7; -.
DR   PhosphoSitePlus; Q9DCC7; -.
DR   EPD; Q9DCC7; -.
DR   jPOST; Q9DCC7; -.
DR   MaxQB; Q9DCC7; -.
DR   PaxDb; Q9DCC7; -.
DR   PeptideAtlas; Q9DCC7; -.
DR   PRIDE; Q9DCC7; -.
DR   ProteomicsDB; 269508; -.
DR   DNASU; 67441; -.
DR   Ensembl; ENSMUST00000064547; ENSMUSP00000066859; ENSMUSG00000052605.
DR   Ensembl; ENSMUST00000208816; ENSMUSP00000147085; ENSMUSG00000052605.
DR   GeneID; 67441; -.
DR   KEGG; mmu:67441; -.
DR   UCSC; uc009eyw.1; mouse.
DR   CTD; 67441; -.
DR   MGI; MGI:1914691; Isoc2b.
DR   VEuPathDB; HostDB:ENSMUSG00000052605; -.
DR   eggNOG; KOG4044; Eukaryota.
DR   GeneTree; ENSGT00390000006753; -.
DR   HOGENOM; CLU_066901_0_1_1; -.
DR   InParanoid; Q9DCC7; -.
DR   OMA; IMTSAPD; -.
DR   OrthoDB; 1100720at2759; -.
DR   PhylomeDB; Q9DCC7; -.
DR   TreeFam; TF313459; -.
DR   BioGRID-ORCS; 67441; 0 hits in 71 CRISPR screens.
DR   ChiTaRS; Isoc2b; mouse.
DR   PRO; PR:Q9DCC7; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q9DCC7; protein.
DR   Bgee; ENSMUSG00000052605; Expressed in right kidney and 124 other tissues.
DR   Genevisible; Q9DCC7; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0031648; P:protein destabilization; ISO:MGI.
DR   Gene3D; 3.40.50.850; -; 1.
DR   InterPro; IPR000868; Isochorismatase-like.
DR   InterPro; IPR036380; Isochorismatase-like_sf.
DR   Pfam; PF00857; Isochorismatase; 1.
DR   SUPFAM; SSF52499; SSF52499; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Isochorismatase domain-containing protein 2B"
FT                   /id="PRO_0000268673"
FT   MOD_RES         178
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0007744|PubMed:23806337"
FT   CONFLICT        40
FT                   /note="K -> M (in Ref. 2; AAH49278)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="C -> R (in Ref. 2; AAH49278)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   210 AA;  23151 MW;  F99B095B4C652229 CRC64;
     MGAAKASLGR IFPESSILFL CDMQEKLRDR ILYFPQIVSK AARMLKVAQM LEIPVLLTEH
     YPQGLGPTVP ELGAQGLRTM SKTSFSMVPP LQQELDKLPQ LQSVLLCGIE TQGCILHTAL
     DLLDRGLQVH VAVDACSSQS EMNRLVALAR MQQSGVFLST SEVLILQLVK DAAHPQFKEI
     QKILKEPVTD IGLLGFFQGK KNSLLPNSRT