ISCA1_DANRE
ID ISCA1_DANRE Reviewed; 129 AA.
AC Q4QRC6;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Iron-sulfur cluster assembly 1 homolog, mitochondrial;
DE AltName: Full=HESB-like domain-containing protein 2;
DE AltName: Full=Iron-sulfur assembly protein IscA;
DE Flags: Precursor;
GN Name=isca1; Synonyms=hbld2; ORFNames=zgc:114185;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Larva;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway. Probably
CC involved in the binding of an intermediate of Fe/S cluster assembly.
CC {ECO:0000250|UniProtKB:Q9BUE6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9BUE6}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC097234; AAH97234.1; -; mRNA.
DR RefSeq; NP_001020349.1; NM_001025178.2.
DR AlphaFoldDB; Q4QRC6; -.
DR SMR; Q4QRC6; -.
DR STRING; 7955.ENSDARP00000068166; -.
DR PaxDb; Q4QRC6; -.
DR Ensembl; ENSDART00000073676; ENSDARP00000068166; ENSDARG00000051956.
DR GeneID; 573999; -.
DR KEGG; dre:573999; -.
DR CTD; 81689; -.
DR ZFIN; ZDB-GENE-050626-94; isca1.
DR eggNOG; KOG1120; Eukaryota.
DR GeneTree; ENSGT00490000043385; -.
DR HOGENOM; CLU_069054_4_0_1; -.
DR InParanoid; Q4QRC6; -.
DR OMA; YQLYFDE; -.
DR OrthoDB; 1578799at2759; -.
DR PhylomeDB; Q4QRC6; -.
DR TreeFam; TF314956; -.
DR Reactome; R-DRE-1362409; Mitochondrial iron-sulfur cluster biogenesis.
DR PRO; PR:Q4QRC6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000051956; Expressed in cardiac ventricle and 24 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006783; P:heme biosynthetic process; IMP:ZFIN.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IBA:GO_Central.
DR Gene3D; 2.60.300.12; -; 1.
DR InterPro; IPR000361; FeS_biogenesis.
DR InterPro; IPR016092; FeS_cluster_insertion.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; SSF89360; 1.
DR TIGRFAMs; TIGR00049; TIGR00049; 1.
DR PROSITE; PS01152; HESB; 1.
PE 2: Evidence at transcript level;
KW Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..12
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 13..129
FT /note="Iron-sulfur cluster assembly 1 homolog,
FT mitochondrial"
FT /id="PRO_0000042739"
FT BINDING 57
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250|UniProtKB:P0AAC8"
FT BINDING 121
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250|UniProtKB:P0AAC8"
FT BINDING 123
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250|UniProtKB:P0AAC8"
SQ SEQUENCE 129 AA; 14248 MW; A777E319DB90D249 CRC64;
MSASIARATV RAVSRRKILS TRAALTLTPS AVNKVKQLLD NKPEYIGLKV GVRTRGCNGL
TYTLDYTKNK EQSDEEVLQD GVRVFIEKKA QLTLLGTEMD FVETKLSSEF VFNNPNIKGT
CGCGESFNI
