ISCA2_BOVIN
ID ISCA2_BOVIN Reviewed; 152 AA.
AC Q2TBG7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Iron-sulfur cluster assembly 2 homolog, mitochondrial;
DE AltName: Full=HESB-like domain-containing protein 1;
DE Flags: Precursor;
GN Name=ISCA2; Synonyms=HBLD1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway. May be
CC involved in the binding of an intermediate of Fe/S cluster assembly.
CC {ECO:0000250|UniProtKB:Q86U28}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q86U28}.
CC -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000305}.
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DR EMBL; BC110251; AAI10252.1; -; mRNA.
DR RefSeq; NP_001033772.1; NM_001038683.2.
DR AlphaFoldDB; Q2TBG7; -.
DR SMR; Q2TBG7; -.
DR STRING; 9913.ENSBTAP00000029272; -.
DR PaxDb; Q2TBG7; -.
DR PRIDE; Q2TBG7; -.
DR Ensembl; ENSBTAT00000029272; ENSBTAP00000029272; ENSBTAG00000021956.
DR GeneID; 613290; -.
DR KEGG; bta:613290; -.
DR CTD; 122961; -.
DR VEuPathDB; HostDB:ENSBTAG00000021956; -.
DR VGNC; VGNC:30291; ISCA2.
DR eggNOG; KOG1119; Eukaryota.
DR GeneTree; ENSGT00390000005700; -.
DR HOGENOM; CLU_069054_1_4_1; -.
DR InParanoid; Q2TBG7; -.
DR OMA; SLDYCTG; -.
DR OrthoDB; 1360948at2759; -.
DR TreeFam; TF314519; -.
DR Reactome; R-BTA-1362409; Mitochondrial iron-sulfur cluster biogenesis.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000021956; Expressed in tongue muscle and 106 other tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IBA:GO_Central.
DR GO; GO:0005506; F:iron ion binding; IBA:GO_Central.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR GO; GO:0106035; P:protein maturation by [4Fe-4S] cluster transfer; IBA:GO_Central.
DR Gene3D; 2.60.300.12; -; 1.
DR InterPro; IPR000361; FeS_biogenesis.
DR InterPro; IPR016092; FeS_cluster_insertion.
DR InterPro; IPR017870; FeS_cluster_insertion_CS.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; SSF89360; 1.
DR TIGRFAMs; TIGR00049; TIGR00049; 1.
DR PROSITE; PS01152; HESB; 1.
PE 2: Evidence at transcript level;
KW Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..6
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 7..152
FT /note="Iron-sulfur cluster assembly 2 homolog,
FT mitochondrial"
FT /id="PRO_0000277587"
FT BINDING 77
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250|UniProtKB:P0AAC8"
FT BINDING 142
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250|UniProtKB:P0AAC8"
FT BINDING 144
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250|UniProtKB:P0AAC8"
SQ SEQUENCE 152 AA; 16436 MW; 4A1CA23F6A710636 CRC64;
MAAVRGLTAV ALRVVTPWQR SRLLAASRGP RALREVSFSS PEAGEGQIHL TDSCVQRLLE
ITEGSEFLRL EVEGGGCSGF QYKFSLDTVI NPDDRVFEKG GARVVVDSDS LAFVKGAHVD
FSQELIRSSF QVLNNPQAQQ GCSCGSSFSV KL
