ID   ISCA2_PONAB             Reviewed;         154 AA.
AC   Q5R788;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Iron-sulfur cluster assembly 2 homolog, mitochondrial;
DE   AltName: Full=HESB-like domain-containing protein 1;
DE   Flags: Precursor;
GN   Name=ISCA2; Synonyms=HBLD1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC       functioning late in the iron-sulfur cluster assembly pathway. May be
CC       involved in the binding of an intermediate of Fe/S cluster assembly.
CC       {ECO:0000250|UniProtKB:Q86U28}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q86U28}.
CC   -!- SIMILARITY: Belongs to the HesB/IscA family. {ECO:0000305}.
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DR   EMBL; CR860230; CAH92372.1; -; mRNA.
DR   RefSeq; NP_001126397.1; NM_001132925.2.
DR   AlphaFoldDB; Q5R788; -.
DR   SMR; Q5R788; -.
DR   STRING; 9601.ENSPPYP00000006807; -.
DR   Ensembl; ENSPPYT00000007076; ENSPPYP00000006807; ENSPPYG00000005988.
DR   GeneID; 100173379; -.
DR   KEGG; pon:100173379; -.
DR   CTD; 122961; -.
DR   eggNOG; KOG1119; Eukaryota.
DR   GeneTree; ENSGT00390000005700; -.
DR   HOGENOM; CLU_069054_1_4_1; -.
DR   InParanoid; Q5R788; -.
DR   OrthoDB; 1360948at2759; -.
DR   Proteomes; UP000001595; Chromosome 14.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   Gene3D; 2.60.300.12; -; 1.
DR   InterPro; IPR000361; FeS_biogenesis.
DR   InterPro; IPR016092; FeS_cluster_insertion.
DR   InterPro; IPR017870; FeS_cluster_insertion_CS.
DR   InterPro; IPR035903; HesB-like_dom_sf.
DR   Pfam; PF01521; Fe-S_biosyn; 1.
DR   SUPFAM; SSF89360; SSF89360; 1.
DR   TIGRFAMs; TIGR00049; TIGR00049; 1.
DR   PROSITE; PS01152; HESB; 1.
PE   2: Evidence at transcript level;
KW   Iron; Iron-sulfur; Metal-binding; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..8
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           9..154
FT                   /note="Iron-sulfur cluster assembly 2 homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000277590"
FT   BINDING         79
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P0AAC8"
FT   BINDING         144
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P0AAC8"
FT   BINDING         146
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:P0AAC8"
SQ   SEQUENCE   154 AA;  16414 MW;  6794585B167C811F CRC64;
     MAAARGLSLT AATQKAVTPW PRGRLLAASL GPQARREASS SSPEAGEGQI RLTDSCVQRL
     LEITEGSEFL RLQVEGGGCS GFQYKFSLDT VINPDDRVFE QGGARVVVDS DSLAFVKGAQ
     VDFSQELIRS SFQVLNNPQA QQGCSCGSSF SIKL