ID   APR_CANLF               Reviewed;          54 AA.
AC   Q1PCT2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Phorbol-12-myristate-13-acetate-induced protein 1;
DE   AltName: Full=Protein Noxa;
GN   Name=PMAIP1; Synonyms=NOXA;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Schade B., Rickenbacher A.B., Keller S.M., Wimmershoff J., Guscetti F.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Promotes activation of caspases and apoptosis. Promotes
CC       mitochondrial membrane changes and efflux of apoptogenic proteins from
CC       the mitochondria. Contributes to p53/TP53-dependent apoptosis after
CC       radiation exposure. Promotes proteasomal degradation of MCL1. Competes
CC       with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1
CC       and BIM/BCL2L11 from their binding sites (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MCL1 (By similarity). Interacts with BCL2A1 (By
CC       similarity). Interacts with BAX (By similarity). Interacts with BCL2L10
CC       (By similarity). {ECO:0000250|UniProtKB:Q13794}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q13794}.
CC   -!- DOMAIN: The BH3 motif is essential for pro-apoptotic activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PMAIP1 family. {ECO:0000305}.
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DR   EMBL; DQ449072; ABE02691.1; -; mRNA.
DR   RefSeq; NP_001182700.1; NM_001195771.1.
DR   AlphaFoldDB; Q1PCT2; -.
DR   SMR; Q1PCT2; -.
DR   STRING; 9612.ENSCAFP00000032282; -.
DR   PaxDb; Q1PCT2; -.
DR   Ensembl; ENSCAFT00000108456; ENSCAFP00000068121; ENSCAFG00000057830.
DR   Ensembl; ENSCAFT00040008159; ENSCAFP00040007110; ENSCAFG00040004265.
DR   Ensembl; ENSCAFT00845000467; ENSCAFP00845000319; ENSCAFG00845000304.
DR   GeneID; 100502558; -.
DR   KEGG; cfa:100502558; -.
DR   CTD; 5366; -.
DR   VEuPathDB; HostDB:ENSCAFG00845000304; -.
DR   eggNOG; ENOG502SEAE; Eukaryota.
DR   GeneTree; ENSGT00530000065105; -.
DR   HOGENOM; CLU_3049644_0_0_1; -.
DR   InParanoid; Q1PCT2; -.
DR   OMA; LITKLFC; -.
DR   OrthoDB; 1636703at2759; -.
DR   Reactome; R-CFA-111448; Activation of NOXA and translocation to mitochondria.
DR   Reactome; R-CFA-111453; BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
DR   Proteomes; UP000002254; Chromosome 1.
DR   Bgee; ENSCAFG00000023829; Expressed in granulocyte and 43 other tissues.
DR   GO; GO:0097136; C:Bcl-2 family protein complex; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:InterPro.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:InterPro.
DR   GO; GO:0042149; P:cellular response to glucose starvation; IEA:Ensembl.
DR   GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR   GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IEA:Ensembl.
DR   GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR   GO; GO:0010907; P:positive regulation of glucose metabolic process; IEA:Ensembl.
DR   GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0090200; P:positive regulation of release of cytochrome c from mitochondria; IEA:Ensembl.
DR   GO; GO:0010498; P:proteasomal protein catabolic process; IEA:Ensembl.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl.
DR   GO; GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Ensembl.
DR   GO; GO:0001836; P:release of cytochrome c from mitochondria; IEA:InterPro.
DR   GO; GO:0043331; P:response to dsRNA; IEA:Ensembl.
DR   InterPro; IPR024140; Noxa.
DR   PANTHER; PTHR14299; PTHR14299; 1.
DR   Pfam; PF15150; PMAIP1; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Mitochondrion; Reference proteome.
FT   CHAIN           1..54
FT                   /note="Phorbol-12-myristate-13-acetate-induced protein 1"
FT                   /id="PRO_0000333229"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          41..50
FT                   /note="Required for mitochondrial location"
FT                   /evidence="ECO:0000250"
FT   MOTIF           29..37
FT                   /note="BH3"
SQ   SEQUENCE   54 AA;  6126 MW;  D5E247F35862C457 CRC64;
     MPGRKARKSA QPGPTRAPEE LEVECAIQLR KFGDKLNFRQ KLLNLLSKLF RSGT