ID   APS3_CANAL              Reviewed;         175 AA.
AC   Q59QC5; A0A1D8PEE5;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Clathrin-associated protein AP-3 complex component APS3;
GN   Name=APS3; OrderedLocusNames=CAALFM_C108480CA;
GN   ORFNames=CaO19.393, CaO19.8023;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION.
RX   PubMed=20870878; DOI=10.1128/ec.00029-10;
RA   Palmer G.E.;
RT   "Endosomal and AP-3-dependent vacuolar trafficking routes make additive
RT   contributions to Candida albicans hyphal growth and pathogenesis.";
RL   Eukaryot. Cell 9:1755-1765(2010).
CC   -!- FUNCTION: Part of the AP-3 complex, an adapter-related complex which is
CC       not clathrin-associated. The complex is associated with the Golgi
CC       region as well as more peripheral structures. It facilitates the
CC       budding of vesicles from the Golgi membrane (By similarity). Involved
CC       in vacuolar trafficking and contributes to hyphal growth and
CC       pathogenesis. {ECO:0000250, ECO:0000269|PubMed:20870878}.
CC   -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC       of 2 large adaptins, a medium adaptin and a small adaptin.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasmic
CC       vesicle membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the
CC       coat surrounding the cytoplasmic face of coated vesicles located at the
CC       Golgi complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; CP017623; AOW26486.1; -; Genomic_DNA.
DR   RefSeq; XP_019330678.1; XM_019475133.1.
DR   AlphaFoldDB; Q59QC5; -.
DR   SMR; Q59QC5; -.
DR   STRING; 237561.Q59QC5; -.
DR   PRIDE; Q59QC5; -.
DR   GeneID; 3646491; -.
DR   KEGG; cal:CAALFM_C108480CA; -.
DR   CGD; CAL0000182525; APS3.
DR   VEuPathDB; FungiDB:C1_08480C_A; -.
DR   eggNOG; KOG0936; Eukaryota.
DR   HOGENOM; CLU_061221_2_0_1; -.
DR   InParanoid; Q59QC5; -.
DR   OMA; DLIFNWQ; -.
DR   OrthoDB; 1458249at2759; -.
DR   PRO; PR:Q59QC5; -.
DR   Proteomes; UP000000559; Chromosome 1.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR000804; Clathrin_sm-chain_CS.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport; Virulence.
FT   CHAIN           1..175
FT                   /note="Clathrin-associated protein AP-3 complex component
FT                   APS3"
FT                   /id="PRO_0000422796"
SQ   SEQUENCE   175 AA;  19760 MW;  22ACAECCD2FDE121 CRC64;
     MIHSVLIFNN DGLPRLMKFY TKVDIPTQKL LLQQVHSLIS TRSAQECSFI TPPSLLEDLD
     DIKVIYRHYA TLYFVFIVDD QESELGILDL IQVFVECLDK CFSNVCELDL VFGWQVLQTV
     LEEIVQGGMV IDTNINRIVA AVDEANSQKN VNSNGSTISA SILSSLSRDR GFWGR