ISCR_SODGM
ID ISCR_SODGM Reviewed; 165 AA.
AC Q2NS30;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=HTH-type transcriptional regulator IscR {ECO:0000255|HAMAP-Rule:MF_01176};
GN Name=iscR {ECO:0000255|HAMAP-Rule:MF_01176}; OrderedLocusNames=SG1770;
OS Sodalis glossinidius (strain morsitans).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Bruguierivoracaceae; Sodalis.
OX NCBI_TaxID=343509;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=morsitans;
RX PubMed=16365377; DOI=10.1101/gr.4106106;
RA Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA Aksoy S.;
RT "Massive genome erosion and functional adaptations provide insights into
RT the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL Genome Res. 16:149-156(2006).
CC -!- FUNCTION: Regulates the transcription of several operons and genes
CC involved in the biogenesis of Fe-S clusters and Fe-S-containing
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01176}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01176};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000255|HAMAP-Rule:MF_01176};
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DR EMBL; AP008232; BAE75045.1; -; Genomic_DNA.
DR RefSeq; WP_011411594.1; NZ_LN854557.1.
DR AlphaFoldDB; Q2NS30; -.
DR SMR; Q2NS30; -.
DR STRING; 343509.SG1770; -.
DR EnsemblBacteria; BAE75045; BAE75045; SG1770.
DR KEGG; sgl:SG1770; -.
DR eggNOG; COG1959; Bacteria.
DR HOGENOM; CLU_107144_0_0_6; -.
DR OMA; YGLTIMM; -.
DR OrthoDB; 1794390at2; -.
DR BioCyc; SGLO343509:SGP1_RS16090-MON; -.
DR Proteomes; UP000001932; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01176; HTH_type_IscR; 1.
DR InterPro; IPR010242; TF_HTH_IscR.
DR InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33221; PTHR33221; 1.
DR Pfam; PF02082; Rrf2; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02010; IscR; 1.
DR TIGRFAMs; TIGR00738; rrf2_super; 1.
DR PROSITE; PS51197; HTH_RRF2_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Activator; DNA-binding; Iron; Iron-sulfur; Metal-binding;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..165
FT /note="HTH-type transcriptional regulator IscR"
FT /id="PRO_0000268929"
FT DOMAIN 2..131
FT /note="HTH rrf2-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT DNA_BIND 28..51
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT REGION 144..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 92
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT BINDING 98
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT BINDING 104
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
SQ SEQUENCE 165 AA; 18079 MW; EE8AAB2ABB50BC7F CRC64;
MRLTSKGRYA VTAMLDVALH SGKGPVPLAE ISERQGISLS YLEQLFSRLR KHELVASVRG
PGGGYLLGRD SDQIAVGAVI TAVDESVDAT RCQGKEGCQG GDRCLTHVLW RDLSVRISEF
LNNITLAELV SNEEILDVVD RQDNDTRRPL TNGRPQETIN VNLHA
