ISCR_VIBVU
ID ISCR_VIBVU Reviewed; 168 AA.
AC Q8DEY6;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=HTH-type transcriptional regulator IscR {ECO:0000255|HAMAP-Rule:MF_01176};
GN Name=iscR {ECO:0000255|HAMAP-Rule:MF_01176}; OrderedLocusNames=VV1_0439;
OS Vibrio vulnificus (strain CMCP6).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=216895;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMCP6;
RA Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates the transcription of several operons and genes
CC involved in the biogenesis of Fe-S clusters and Fe-S-containing
CC proteins. {ECO:0000255|HAMAP-Rule:MF_01176}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01176};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000255|HAMAP-Rule:MF_01176};
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO08962.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE016795; AAO08962.2; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_013572351.1; NC_004459.3.
DR AlphaFoldDB; Q8DEY6; -.
DR SMR; Q8DEY6; -.
DR EnsemblBacteria; AAO08962; AAO08962; VV1_0439.
DR GeneID; 66964022; -.
DR KEGG; vvu:VV1_0439; -.
DR HOGENOM; CLU_107144_0_0_6; -.
DR OMA; YGLTIMM; -.
DR Proteomes; UP000002275; Chromosome 1.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_01176; HTH_type_IscR; 1.
DR InterPro; IPR010242; TF_HTH_IscR.
DR InterPro; IPR030489; TR_Rrf2-type_CS.
DR InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33221; PTHR33221; 1.
DR Pfam; PF02082; Rrf2; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR02010; IscR; 1.
DR TIGRFAMs; TIGR00738; rrf2_super; 1.
DR PROSITE; PS01332; HTH_RRF2_1; 1.
DR PROSITE; PS51197; HTH_RRF2_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; Activator; DNA-binding; Iron; Iron-sulfur; Metal-binding;
KW Repressor; Transcription; Transcription regulation.
FT CHAIN 1..168
FT /note="HTH-type transcriptional regulator IscR"
FT /id="PRO_0000268932"
FT DOMAIN 2..131
FT /note="HTH rrf2-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT DNA_BIND 28..51
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT BINDING 92
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT BINDING 98
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
FT BINDING 104
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01176"
SQ SEQUENCE 168 AA; 18008 MW; 17A128A6AB6D651C CRC64;
MKLTSKGRYA VTAMLDVALH SQKSPVPLAD ISERQGISLS YLEQLFSKLR KAGLVASVRG
PGGGYRLGAD AFTISIGTVI AAVDESVDAT KCQGKGDCQG GTRCLTHTLW RDLSSRITDF
LNNITLGELM SDNEVIEISD RQDIDLAVNH GLANKTINTA PIGVNFRS
