ID   APT1_WHEAT              Reviewed;         181 AA.
AC   Q43199;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Adenine phosphoribosyltransferase 1;
DE            Short=APRT 1;
DE            EC=2.4.2.7;
GN   Name=APT1;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Capitole; TISSUE=Seed;
RA   Moffatt B.A., Schnorr K.S., Gaillard C., Biget E., Laloue M.;
RT   "Nucleotide sequence of a wheat cDNA encoding adenine
RT   phosphoribosyltransferase.";
RL   (er) Plant Gene Register PGR95-030(1995).
CC   -!- FUNCTION: Catalyzes a salvage reaction resulting in the formation of
CC       AMP, that is energically less costly than de novo synthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=2.4.2.7;
CC   -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC       from adenine: step 1/1.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
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DR   EMBL; U22442; AAA80609.1; -; mRNA.
DR   PIR; T06263; T06263.
DR   AlphaFoldDB; Q43199; -.
DR   SMR; Q43199; -.
DR   STRING; 4565.Traes_5BS_1012AD486.1; -.
DR   PRIDE; Q43199; -.
DR   EnsemblPlants; TraesCAD_scaffold_035238_01G000200.1; TraesCAD_scaffold_035238_01G000200.1; TraesCAD_scaffold_035238_01G000200.
DR   EnsemblPlants; TraesCLE_scaffold_031857_01G000200.1; TraesCLE_scaffold_031857_01G000200.1; TraesCLE_scaffold_031857_01G000200.
DR   EnsemblPlants; TraesPAR_scaffold_093320_01G000200.1; TraesPAR_scaffold_093320_01G000200.1; TraesPAR_scaffold_093320_01G000200.
DR   EnsemblPlants; TraesROB_scaffold_030035_01G000100.1; TraesROB_scaffold_030035_01G000100.1; TraesROB_scaffold_030035_01G000100.
DR   EnsemblPlants; TraesWEE_scaffold_069101_01G000200.1; TraesWEE_scaffold_069101_01G000200.1; TraesWEE_scaffold_069101_01G000200.
DR   Gramene; TraesCAD_scaffold_035238_01G000200.1; TraesCAD_scaffold_035238_01G000200.1; TraesCAD_scaffold_035238_01G000200.
DR   Gramene; TraesCLE_scaffold_031857_01G000200.1; TraesCLE_scaffold_031857_01G000200.1; TraesCLE_scaffold_031857_01G000200.
DR   Gramene; TraesPAR_scaffold_093320_01G000200.1; TraesPAR_scaffold_093320_01G000200.1; TraesPAR_scaffold_093320_01G000200.
DR   Gramene; TraesROB_scaffold_030035_01G000100.1; TraesROB_scaffold_030035_01G000100.1; TraesROB_scaffold_030035_01G000100.
DR   Gramene; TraesWEE_scaffold_069101_01G000200.1; TraesWEE_scaffold_069101_01G000200.1; TraesWEE_scaffold_069101_01G000200.
DR   eggNOG; KOG1712; Eukaryota.
DR   BRENDA; 2.4.2.7; 6500.
DR   SABIO-RK; Q43199; -.
DR   UniPathway; UPA00588; UER00646.
DR   Proteomes; UP000019116; Unplaced.
DR   ExpressionAtlas; Q43199; baseline.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003999; F:adenine phosphoribosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006168; P:adenine salvage; IEA:InterPro.
DR   GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_00004; Aden_phosphoribosyltr; 1.
DR   InterPro; IPR005764; Ade_phspho_trans.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01090; apt; 1.
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Glycosyltransferase; Purine salvage; Reference proteome;
KW   Transferase.
FT   CHAIN           1..181
FT                   /note="Adenine phosphoribosyltransferase 1"
FT                   /id="PRO_0000149516"
SQ   SEQUENCE   181 AA;  19664 MW;  3325FBCF3780B24C CRC64;
     MASDGRVERI ASSIRAIPNF PKPGILFQDI TTLLLDPQAF RDTTDLFVER YKDKDITVVA
     GVEARGFIFG PPIALAIGAK FVPIRKPKKL PGEVISEEYS LEYGTDKIEM HVGAVQPNDR
     VLIVDDLIAT GGTLCAAAKL IERVGAKVVE CACVIELPEL KGRDKLGDMP VFVLVQADES
     V