ID   APT2_RHIEC              Reviewed;         184 AA.
AC   Q8KKS1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Adenine phosphoribosyltransferase 2 {ECO:0000255|HAMAP-Rule:MF_00004};
DE            Short=APRT 2 {ECO:0000255|HAMAP-Rule:MF_00004};
DE            EC=2.4.2.7 {ECO:0000255|HAMAP-Rule:MF_00004};
GN   Name=apt2 {ECO:0000255|HAMAP-Rule:MF_00004}; OrderedLocusNames=RHE_PD00341;
OS   Rhizobium etli (strain CFN 42 / ATCC 51251).
OG   Plasmid sym p42d.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX   NCBI_TaxID=347834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=12801410; DOI=10.1186/gb-2003-4-6-r36;
RA   Gonzalez V., Bustos P., Ramirez-Romero M.A., Medrano-Soto A., Salgado H.,
RA   Hernandez-Gonzalez I., Hernandez-Celis J.C., Quintero V.,
RA   Moreno-Hagelsieb G., Girard L., Rodriguez O., Flores M., Cevallos M.A.,
RA   Collado-Vides J., Romero D., Davila G.;
RT   "The mosaic structure of the symbiotic plasmid of Rhizobium etli CFN42 and
RT   its relation to other symbiotic genome compartments.";
RL   Genome Biol. 4:R36.1-R36.13(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFN 42 / ATCC 51251;
RX   PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA   Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA   Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA   Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT   "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT   seven interacting replicons.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
CC   -!- FUNCTION: Catalyzes a salvage reaction resulting in the formation of
CC       AMP, that is energically less costly than de novo synthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00004}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         adenine; Xref=Rhea:RHEA:16609, ChEBI:CHEBI:16708, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58017, ChEBI:CHEBI:456215; EC=2.4.2.7;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00004};
CC   -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC       from adenine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00004}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00004}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00004}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000255|HAMAP-Rule:MF_00004}.
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DR   EMBL; U80928; AAM55053.2; -; Genomic_DNA.
DR   RefSeq; WP_004672710.1; NC_004041.2.
DR   AlphaFoldDB; Q8KKS1; -.
DR   SMR; Q8KKS1; -.
DR   EnsemblBacteria; AAM55053; AAM55053; RHE_PD00341.
DR   GeneID; 45960677; -.
DR   GeneID; 58692310; -.
DR   KEGG; ret:RHE_PD00341; -.
DR   HOGENOM; CLU_063339_3_0_5; -.
DR   OMA; EYSCEYC; -.
DR   UniPathway; UPA00588; UER00646.
DR   Proteomes; UP000001936; Plasmid sym p42d.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003999; F:adenine phosphoribosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006168; P:adenine salvage; IEA:UniProtKB-UniRule.
DR   GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   HAMAP; MF_00004; Aden_phosphoribosyltr; 1.
DR   InterPro; IPR005764; Ade_phspho_trans.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycosyltransferase; Plasmid; Purine salvage;
KW   Reference proteome; Transferase.
FT   CHAIN           1..184
FT                   /note="Adenine phosphoribosyltransferase 2"
FT                   /id="PRO_0000334716"
SQ   SEQUENCE   184 AA;  19027 MW;  9B715686CDB75F91 CRC64;
     MIVAVPNSGA SRINQSGVEA LREFPNFPIG GILFKDIAPM LAGRGALGEV VSTVASQVSG
     TEIDAILAVD ARGFILGASL ADRLGCGFIM VRKPGKLPGD VLSFEYSCEY CSGTLEVTAG
     LIGDGLRCLI ADDLLATGGT ARATGNFVKS QGGEIAGYAF ILEIEVLKGR RQLDDAPVIS
     AMTC