ID   ISCU1_ARCFU             Reviewed;         153 AA.
AC   P0DMG1; O34393;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Iron-sulfur cluster assembly scaffold protein IscU 1;
DE   AltName: Full=Sulfur acceptor protein IscU 1;
GN   Name=iscU1; OrderedLocusNames=AF_0185;
OS   Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS   100126 / VC-16).
OC   Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC   Archaeoglobus.
OX   NCBI_TaxID=224325;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX   PubMed=9389475; DOI=10.1038/37052;
RA   Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA   Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA   Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA   Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA   Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA   Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA   Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA   Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA   Smith H.O., Woese C.R., Venter J.C.;
RT   "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT   archaeon Archaeoglobus fulgidus.";
RL   Nature 390:364-370(1997).
CC   -!- FUNCTION: A scaffold on which IscS assembles Fe-S clusters.
CC       Subsequently gives the nascent cluster to other proteins. It is likely
CC       that Fe-S cluster coordination is flexible as the role of this complex
CC       is to build and then hand off Fe-S clusters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterotetramer with IscS2. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
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DR   EMBL; AE000782; AAB90674.1; -; Genomic_DNA.
DR   PIR; A69273; A69273.
DR   RefSeq; WP_010877697.1; NC_000917.1.
DR   AlphaFoldDB; P0DMG1; -.
DR   SMR; P0DMG1; -.
DR   STRING; 224325.AF_0185; -.
DR   EnsemblBacteria; AAB90674; AAB90674; AF_0565.
DR   GeneID; 24794105; -.
DR   KEGG; afu:AF_0565; -.
DR   eggNOG; arCOG02077; Archaea.
DR   HOGENOM; CLU_079283_5_1_2; -.
DR   OMA; HKKVIDH; -.
DR   OrthoDB; 89731at2157; -.
DR   PhylomeDB; P0DMG1; -.
DR   Proteomes; UP000002199; Chromosome.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd06664; IscU_like; 1.
DR   InterPro; IPR017787; NIF_FeS_clus_asmbl_NifU-like.
DR   InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N.
DR   PANTHER; PTHR10093; PTHR10093; 1.
DR   Pfam; PF01592; NifU_N; 1.
DR   TIGRFAMs; TIGR03419; NifU_clost; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; Iron; Iron-sulfur; Metal-binding; Reference proteome.
FT   CHAIN           1..153
FT                   /note="Iron-sulfur cluster assembly scaffold protein IscU
FT                   1"
FT                   /id="PRO_0000428754"
FT   BINDING         33
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /ligand_note="ligand shared with IscS"
FT                   /evidence="ECO:0000250|UniProtKB:P0DMG2"
FT   BINDING         58
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /ligand_note="ligand shared with IscS"
FT                   /evidence="ECO:0000250|UniProtKB:P0DMG2"
FT   BINDING         101
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /ligand_note="ligand shared with IscS"
FT                   /evidence="ECO:0000250|UniProtKB:P0DMG2"
FT   BINDING         102
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /ligand_note="ligand shared with IscS"
FT                   /evidence="ECO:0000250|UniProtKB:P0DMG2"
SQ   SEQUENCE   153 AA;  16920 MW;  ABC2DD8023EE8185 CRC64;
     MYSDKVFDHF QNPRNVGKIE DADGVGTVGN PVCGDLMTIY IKVKDNRIED IKFQTFGCAA
     AIATSSMATE MAKGKTIEEA LKITRDAVAE ALGGLPKQKM HCSNLAADAL RRAIVDYFRK
     NGKIDKIKEL GLEKELEKME KGEMDDHGEY CEA