ID   ISCU_BUCAI              Reviewed;         127 AA.
AC   P57658;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Iron-sulfur cluster assembly scaffold protein IscU;
DE   AltName: Full=Sulfur acceptor protein IscU;
GN   Name=iscU; Synonyms=nifU; OrderedLocusNames=BU603;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: A scaffold on which IscS assembles Fe-S clusters.
CC       Subsequently gives the nascent cluster to other proteins. It is likely
CC       that Fe-S cluster coordination is flexible as the role of this complex
CC       is to build and then hand off Fe-S clusters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterotetramer with IscS; each subunit of the IscS
CC       dimer contacts an IscU monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000003; BAB13287.1; -; Genomic_DNA.
DR   RefSeq; NP_240401.1; NC_002528.1.
DR   RefSeq; WP_009874550.1; NC_002528.1.
DR   AlphaFoldDB; P57658; -.
DR   SMR; P57658; -.
DR   STRING; 107806.10039253; -.
DR   EnsemblBacteria; BAB13287; BAB13287; BAB13287.
DR   KEGG; buc:BU603; -.
DR   PATRIC; fig|107806.10.peg.605; -.
DR   eggNOG; COG0822; Bacteria.
DR   HOGENOM; CLU_079283_5_0_6; -.
DR   OMA; YKNPRNY; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd06664; IscU_like; 1.
DR   InterPro; IPR011339; ISC_FeS_clus_asmbl_IscU.
DR   InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N.
DR   PANTHER; PTHR10093; PTHR10093; 1.
DR   Pfam; PF01592; NifU_N; 1.
DR   TIGRFAMs; TIGR01999; iscU; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..127
FT                   /note="Iron-sulfur cluster assembly scaffold protein IscU"
FT                   /id="PRO_0000166181"
SQ   SEQUENCE   127 AA;  13711 MW;  4F8AA1B36B6A7B15 CRC64;
     MAYSKKVMDH YENPRNVGSF SSTDLNVGSG LVGAPACGDV MKLQIKVNEK GIIEDACFKT
     YGCGSAIASS SLVTEWVKGK SIEEAESIKN TTIVEELDLP PVKIHCSILA EDAIKAAISD
     YKRKKIN