ID   ISCU_BUCAP              Reviewed;         128 AA.
AC   O51885;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Iron-sulfur cluster assembly scaffold protein IscU;
DE   AltName: Full=Sulfur acceptor protein IscU;
GN   Name=iscU; Synonyms=nifU; OrderedLocusNames=BUsg_578;
OS   Buchnera aphidicola subsp. Schizaphis graminum (strain Sg).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=198804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9516544; DOI=10.1007/pl00006760;
RA   Clark M.A., Baumann L., Baumann P.;
RT   "Sequence analysis of a 34.7-kb DNA segment from the genome of Buchnera
RT   aphidicola (endosymbiont of aphids) containing groEL, dnaA, the atp operon,
RT   gidA, and rho.";
RL   Curr. Microbiol. 36:158-163(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sg;
RX   PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- FUNCTION: A scaffold on which IscS assembles Fe-S clusters.
CC       Subsequently gives the nascent cluster to other proteins. It is likely
CC       that Fe-S cluster coordination is flexible as the role of this complex
CC       is to build and then hand off Fe-S clusters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterotetramer with IscS; each subunit of the IscS
CC       dimer contacts an IscU monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
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DR   EMBL; AF008210; AAC38123.1; -; Genomic_DNA.
DR   EMBL; AE013218; AAM68112.1; -; Genomic_DNA.
DR   RefSeq; WP_011054078.1; NC_004061.1.
DR   AlphaFoldDB; O51885; -.
DR   SMR; O51885; -.
DR   STRING; 198804.BUsg_578; -.
DR   EnsemblBacteria; AAM68112; AAM68112; BUsg_578.
DR   KEGG; bas:BUsg_578; -.
DR   eggNOG; COG0822; Bacteria.
DR   HOGENOM; CLU_079283_5_0_6; -.
DR   OMA; YKNPRNY; -.
DR   OrthoDB; 1793654at2; -.
DR   Proteomes; UP000000416; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd06664; IscU_like; 1.
DR   InterPro; IPR011339; ISC_FeS_clus_asmbl_IscU.
DR   InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N.
DR   PANTHER; PTHR10093; PTHR10093; 1.
DR   Pfam; PF01592; NifU_N; 1.
DR   TIGRFAMs; TIGR01999; iscU; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..128
FT                   /note="Iron-sulfur cluster assembly scaffold protein IscU"
FT                   /id="PRO_0000166182"
SQ   SEQUENCE   128 AA;  13728 MW;  E52A31993822B050 CRC64;
     MAYSKKVMDH YENPRNVGSF SNSDSNVGSG LVGAPACGDV MKLQIKVNEQ GIIEDACFKT
     YGCGSAIASS SLVTEWIKGK SITEAEAIKN TSIVEELELP PVKIHCSILA EDAIKAAISD
     YKSKKNKN