ID   ISCU_ECOL6              Reviewed;         128 AA.
AC   P0ACD5; P77310;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Iron-sulfur cluster assembly scaffold protein IscU;
DE   AltName: Full=Sulfur acceptor protein IscU;
GN   Name=iscU; Synonyms=nifU; OrderedLocusNames=c3055;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: A scaffold on which IscS assembles Fe-S clusters.
CC       Subsequently gives the nascent cluster to other proteins. It is likely
CC       that Fe-S cluster coordination is flexible as the role of this complex
CC       is to build and then hand off Fe-S clusters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterotetramer with IscS; each subunit of the IscS
CC       dimer contacts an IscU monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN81505.1; -; Genomic_DNA.
DR   RefSeq; WP_000331707.1; NC_004431.1.
DR   AlphaFoldDB; P0ACD5; -.
DR   BMRB; P0ACD5; -.
DR   SMR; P0ACD5; -.
DR   STRING; 199310.c3055; -.
DR   EnsemblBacteria; AAN81505; AAN81505; c3055.
DR   GeneID; 67416913; -.
DR   KEGG; ecc:c3055; -.
DR   eggNOG; COG0822; Bacteria.
DR   HOGENOM; CLU_079283_5_0_6; -.
DR   OMA; YKNPRNY; -.
DR   BioCyc; ECOL199310:C3055-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd06664; IscU_like; 1.
DR   InterPro; IPR011339; ISC_FeS_clus_asmbl_IscU.
DR   InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N.
DR   PANTHER; PTHR10093; PTHR10093; 1.
DR   Pfam; PF01592; NifU_N; 1.
DR   TIGRFAMs; TIGR01999; iscU; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..128
FT                   /note="Iron-sulfur cluster assembly scaffold protein IscU"
FT                   /id="PRO_0000166186"
SQ   SEQUENCE   128 AA;  13849 MW;  47516021442B6535 CRC64;
     MAYSEKVIDH YENPRNVGSF DNNDENVGSG MVGAPACGDV MKLQIKVNDE GIIEDARFKT
     YGCGSAIASS SLVTEWVKGK SLDEAQAIKN TDIAEELELP PVKIHCSILA EDAIKAAIAD
     YKSKREAK