ID   ISCU_RICPR              Reviewed;         131 AA.
AC   Q9ZD61;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Iron-sulfur cluster assembly scaffold protein IscU;
DE   AltName: Full=Sulfur acceptor protein IscU;
GN   Name=iscU; Synonyms=nifU; OrderedLocusNames=RP485;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: A scaffold on which IscS assembles Fe-S clusters.
CC       Subsequently gives the nascent cluster to other proteins. It is likely
CC       that Fe-S cluster coordination is flexible as the role of this complex
CC       is to build and then hand off Fe-S clusters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterotetramer with IscS; each subunit of the IscS
CC       dimer contacts an IscU monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
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DR   EMBL; AJ235272; CAA14938.1; -; Genomic_DNA.
DR   PIR; H71651; H71651.
DR   RefSeq; NP_220862.1; NC_000963.1.
DR   RefSeq; WP_004599506.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZD61; -.
DR   SMR; Q9ZD61; -.
DR   STRING; 272947.RP485; -.
DR   EnsemblBacteria; CAA14938; CAA14938; CAA14938.
DR   GeneID; 57569610; -.
DR   KEGG; rpr:RP485; -.
DR   PATRIC; fig|272947.5.peg.495; -.
DR   eggNOG; COG0822; Bacteria.
DR   HOGENOM; CLU_079283_5_0_5; -.
DR   OMA; YKNPRNY; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd06664; IscU_like; 1.
DR   InterPro; IPR011339; ISC_FeS_clus_asmbl_IscU.
DR   InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N.
DR   PANTHER; PTHR10093; PTHR10093; 1.
DR   Pfam; PF01592; NifU_N; 1.
DR   TIGRFAMs; TIGR01999; iscU; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..131
FT                   /note="Iron-sulfur cluster assembly scaffold protein IscU"
FT                   /id="PRO_0000166188"
SQ   SEQUENCE   131 AA;  14223 MW;  CBC418A66272AD74 CRC64;
     MAYSKKVIDH YENPRNVGSL DKKKKNVGTG LVGAPACGDV MKLQIEVGDD EIITDAKFKT
     FGCGSAIASS SLVTEWIKGK SVEDAKEIKN TEIAKELSLP PVKLHCSLLA EDAIKAAIAD
     YKQKRENKKD S