ID   ISCU_SHIFL              Reviewed;         128 AA.
AC   P0ACD7; P77310;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Iron-sulfur cluster assembly scaffold protein IscU;
DE   AltName: Full=Sulfur acceptor protein IscU;
GN   Name=iscU; Synonyms=nifU; OrderedLocusNames=SF2576, S2748;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: A scaffold on which IscS assembles Fe-S clusters.
CC       Subsequently gives the nascent cluster to other proteins. It is likely
CC       that Fe-S cluster coordination is flexible as the role of this complex
CC       is to build and then hand off Fe-S clusters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterotetramer with IscS; each subunit of the IscS
CC       dimer contacts an IscU monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
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DR   EMBL; AE005674; AAN44075.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP17900.1; -; Genomic_DNA.
DR   RefSeq; NP_708368.1; NC_004337.2.
DR   RefSeq; WP_000331707.1; NZ_WPGW01000021.1.
DR   AlphaFoldDB; P0ACD7; -.
DR   BMRB; P0ACD7; -.
DR   SMR; P0ACD7; -.
DR   STRING; 198214.SF2576; -.
DR   EnsemblBacteria; AAN44075; AAN44075; SF2576.
DR   EnsemblBacteria; AAP17900; AAP17900; S2748.
DR   GeneID; 1026942; -.
DR   GeneID; 67416913; -.
DR   KEGG; sfl:SF2576; -.
DR   KEGG; sfx:S2748; -.
DR   PATRIC; fig|198214.7.peg.3076; -.
DR   HOGENOM; CLU_079283_5_0_6; -.
DR   OMA; YKNPRNY; -.
DR   OrthoDB; 1793654at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd06664; IscU_like; 1.
DR   InterPro; IPR011339; ISC_FeS_clus_asmbl_IscU.
DR   InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N.
DR   PANTHER; PTHR10093; PTHR10093; 1.
DR   Pfam; PF01592; NifU_N; 1.
DR   TIGRFAMs; TIGR01999; iscU; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..128
FT                   /note="Iron-sulfur cluster assembly scaffold protein IscU"
FT                   /id="PRO_0000166189"
SQ   SEQUENCE   128 AA;  13849 MW;  47516021442B6535 CRC64;
     MAYSEKVIDH YENPRNVGSF DNNDENVGSG MVGAPACGDV MKLQIKVNDE GIIEDARFKT
     YGCGSAIASS SLVTEWVKGK SLDEAQAIKN TDIAEELELP PVKIHCSILA EDAIKAAIAD
     YKSKREAK