ID   ISCU_THEMA              Reviewed;         142 AA.
AC   Q9X192;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Iron-sulfur cluster assembly scaffold protein IscU;
DE   AltName: Full=Sulfur acceptor protein IscU;
GN   Name=iscU; Synonyms=nifU; OrderedLocusNames=TM_1372;
OS   Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS   / MSB8).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA   Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA   Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA   Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA   Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
CC   -!- FUNCTION: A scaffold on which IscS assembles Fe-S clusters.
CC       Subsequently gives the nascent cluster to other proteins. It is likely
CC       that Fe-S cluster coordination is flexible as the role of this complex
CC       is to build and then hand off Fe-S clusters (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterotetramer with IscS; each subunit of the IscS
CC       dimer contacts an IscU monomer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NifU family. {ECO:0000305}.
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DR   EMBL; AE000512; AAD36442.1; -; Genomic_DNA.
DR   PIR; E72260; E72260.
DR   RefSeq; NP_229173.1; NC_000853.1.
DR   AlphaFoldDB; Q9X192; -.
DR   SMR; Q9X192; -.
DR   STRING; 243274.THEMA_07475; -.
DR   EnsemblBacteria; AAD36442; AAD36442; TM_1372.
DR   KEGG; tma:TM1372; -.
DR   PATRIC; fig|243274.18.peg.1441; -.
DR   eggNOG; COG0822; Bacteria.
DR   InParanoid; Q9X192; -.
DR   OMA; MKLDSMY; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IBA:GO_Central.
DR   GO; GO:0008198; F:ferrous iron binding; IBA:GO_Central.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IBA:GO_Central.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   CDD; cd06664; IscU_like; 1.
DR   InterPro; IPR002871; NIF_FeS_clus_asmbl_NifU_N.
DR   PANTHER; PTHR10093; PTHR10093; 1.
DR   Pfam; PF01592; NifU_N; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..142
FT                   /note="Iron-sulfur cluster assembly scaffold protein IscU"
FT                   /id="PRO_0000166190"
SQ   SEQUENCE   142 AA;  16071 MW;  FC2935B469D2CCBE CRC64;
     MVFKMMYSEA ILDYANSKKF RGKLDDATVI EEGKNISCGD EITLYLKVED GVVKDAKFEG
     MGCVISQASA SLMLERIIGE RVEEIFSLIE EAEKMSRGEN FDEGKLKNVT LMSDIKNYPA
     RVKCFILAWK TLKEALKKIS RP