ID   ISCX_ECO57              Reviewed;          66 AA.
AC   P0C0M0; P37096;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Protein IscX;
GN   Name=iscX; OrderedLocusNames=Z3791, ECs3390;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [3]
RP   INTERACTION WITH CYAY; ISCS AND ISCU, AND SUBUNIT.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=20404999; DOI=10.1371/journal.pbio.1000354;
RA   Shi R., Proteau A., Villarroya M., Moukadiri I., Zhang L., Trempe J.F.,
RA   Matte A., Armengod M.E., Cygler M.;
RT   "Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by
RT   IscS protein-protein interactions.";
RL   PLoS Biol. 8:E1000354-E1000354(2010).
CC   -!- FUNCTION: May function as iron donor in the assembly of iron-sulfur
CC       clusters. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer (By similarity). Binds IscS; certain pairs of proteins
CC       can bind simultaneously to IscS; IscS-IscU-CyaY and IscS-IscU-IscX
CC       complexes can be isolated in vitro, but others (IscS-IscX-TusA) cannot.
CC       {ECO:0000250, ECO:0000269|PubMed:20404999}.
CC   -!- INTERACTION:
CC       P0C0M0; P0A6B9: iscS; NbExp=2; IntAct=EBI-15849987, EBI-9011195;
CC   -!- SIMILARITY: Belongs to the IscX family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57638.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36813.1; -; Genomic_DNA.
DR   PIR; B85897; B85897.
DR   PIR; F91052; F91052.
DR   RefSeq; NP_311417.1; NC_002695.1.
DR   RefSeq; WP_000523616.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0C0M0; -.
DR   BMRB; P0C0M0; -.
DR   SMR; P0C0M0; -.
DR   DIP; DIP-58578N; -.
DR   IntAct; P0C0M0; 2.
DR   STRING; 155864.EDL933_3686; -.
DR   EnsemblBacteria; AAG57638; AAG57638; Z3791.
DR   EnsemblBacteria; BAB36813; BAB36813; ECs_3390.
DR   GeneID; 67416908; -.
DR   GeneID; 913777; -.
DR   KEGG; ece:Z3791; -.
DR   KEGG; ecs:ECs_3390; -.
DR   PATRIC; fig|386585.9.peg.3541; -.
DR   eggNOG; COG2975; Bacteria.
DR   HOGENOM; CLU_168040_1_0_6; -.
DR   OMA; AIQQAWI; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:InterPro.
DR   Gene3D; 1.10.10.600; -; 1.
DR   InterPro; IPR007479; ISC_FeS_clus_asmbl_IscsX.
DR   InterPro; IPR036762; IscX-like_sf.
DR   PANTHER; PTHR37532; PTHR37532; 1.
DR   Pfam; PF04384; Fe-S_assembly; 1.
DR   PIRSF; PIRSF039003; IscX; 1.
DR   SUPFAM; SSF140319; SSF140319; 1.
DR   TIGRFAMs; TIGR03412; iscX_yfhJ; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..66
FT                   /note="Protein IscX"
FT                   /id="PRO_0000211854"
SQ   SEQUENCE   66 AA;  7732 MW;  31C176F0C906AAD7 CRC64;
     MGLKWTDSRE IGEALYDAYP DLDPKTVRFT DMHQWICDLE DFDDDPQASN EKILEAILLV
     WLDEAE