ISD11_YEAST
ID ISD11_YEAST Reviewed; 94 AA.
AC Q6Q560; D3DLV0;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein ISD11;
DE AltName: Full=Iron-sulfur protein biogenesis, desulfurase-interacting protein 11;
GN Name=ISD11; OrderedLocusNames=YER048W-A;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH NFS1.
RX PubMed=16341090; DOI=10.1038/sj.emboj.7600905;
RA Adam A.C., Bornhoevd C., Prokisch H., Neupert W., Hell K.;
RT "The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster
RT biogenesis in mitochondria.";
RL EMBO J. 25:174-183(2006).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16823961; DOI=10.1021/pr050477f;
RA Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.;
RT "Toward the complete yeast mitochondrial proteome: multidimensional
RT separation techniques for mitochondrial proteomics.";
RL J. Proteome Res. 5:1543-1554(2006).
CC -!- FUNCTION: Required for mitochondrial iron-sulfur proteins biosynthesis.
CC {ECO:0000269|PubMed:16341090}.
CC -!- SUBUNIT: Interacts with NFS1. {ECO:0000269|PubMed:16341090}.
CC -!- INTERACTION:
CC Q6Q560; P25374: NFS1; NbExp=10; IntAct=EBI-784315, EBI-11991;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:16341090, ECO:0000269|PubMed:16823961}.
CC -!- MISCELLANEOUS: Present with 2440 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U18796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY558455; AAS56781.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07704.1; -; Genomic_DNA.
DR RefSeq; NP_010968.1; NM_001184330.1.
DR AlphaFoldDB; Q6Q560; -.
DR SMR; Q6Q560; -.
DR BioGRID; 36787; 66.
DR ComplexPortal; CPX-392; Mitochondrial NIAUFX iron-sulfur cluster assembly complex.
DR IntAct; Q6Q560; 3.
DR MINT; Q6Q560; -.
DR STRING; 4932.YER048W-A; -.
DR MaxQB; Q6Q560; -.
DR PaxDb; Q6Q560; -.
DR PRIDE; Q6Q560; -.
DR DNASU; 856774; -.
DR EnsemblFungi; YER048W-A_mRNA; YER048W-A; YER048W-A.
DR GeneID; 856774; -.
DR KEGG; sce:YER048W-A; -.
DR SGD; S000007237; ISD11.
DR VEuPathDB; FungiDB:YER048W-A; -.
DR eggNOG; KOG3801; Eukaryota.
DR GeneTree; ENSGT00940000170978; -.
DR HOGENOM; CLU_120076_2_1_1; -.
DR InParanoid; Q6Q560; -.
DR OMA; AYNYRMY; -.
DR BioCyc; YEAST:G3O-30385-MON; -.
DR Reactome; R-SCE-1362409; Mitochondrial iron-sulfur cluster biogenesis.
DR PRO; PR:Q6Q560; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; Q6Q560; protein.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:SGD.
DR GO; GO:1990229; C:iron-sulfur cluster assembly complex; IC:ComplexPortal.
DR GO; GO:1990221; C:L-cysteine desulfurase complex; IPI:SGD.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IMP:SGD.
DR CDD; cd20264; Complex1_LYR_LYRM4; 1.
DR InterPro; IPR008011; Complex1_LYR_dom.
DR InterPro; IPR045297; Complex1_LYR_LYRM4.
DR Pfam; PF05347; Complex1_LYR; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..94
FT /note="Protein ISD11"
FT /id="PRO_0000245364"
SQ SEQUENCE 94 AA; 11266 MW; 5FC241A528BCCB2A CRC64;
MPGFTAPTRR QVLSLYKEFI KNANQFNNYN FREYFLSKTR TTFRKNMNQQ DPKVLMNLFK
EAKNDLGVLK RQSVISQMYT FDRLVVEPLQ GRKH
