ID   APTA_PHOV8              Reviewed;         281 AA.
AC   A6KXB4;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Apulose-4-phosphate transketolase subunit A {ECO:0000305};
DE            EC=2.2.1.13 {ECO:0000269|PubMed:29867142};
DE   AltName: Full=Apulose-4-phosphate transketolase N-terminal subunit {ECO:0000305};
GN   Name=aptA {ECO:0000305|PubMed:29867142};
GN   OrderedLocusNames=BVU_0359 {ECO:0000312|EMBL:ABR38078.1};
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC   11154;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
RN   [2]
RP   FUNCTION, CATALYTIC ACTIVITY, PATHWAY, AND SUBUNIT.
RX   PubMed=29867142; DOI=10.1038/s41589-018-0067-7;
RA   Carter M.S., Zhang X., Huang H., Bouvier J.T., Francisco B.S.,
RA   Vetting M.W., Al-Obaidi N., Bonanno J.B., Ghosh A., Zallot R.G.,
RA   Andersen H.M., Almo S.C., Gerlt J.A.;
RT   "Functional assignment of multiple catabolic pathways for D-apiose.";
RL   Nat. Chem. Biol. 14:696-705(2018).
CC   -!- FUNCTION: Involved in catabolism of D-apiose. Catalyzes the transfer of
CC       the glycolaldehyde group from apulose-4-phosphate to D-glyceraldehyde
CC       3-phosphate, generating dihydroxyacetone phosphate and D-xylulose-5-
CC       phosphate. {ECO:0000269|PubMed:29867142}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-
CC         xylulose 5-phosphate + dihydroxyacetone phosphate;
CC         Xref=Rhea:RHEA:57024, ChEBI:CHEBI:57642, ChEBI:CHEBI:57737,
CC         ChEBI:CHEBI:59776, ChEBI:CHEBI:141351; EC=2.2.1.13;
CC         Evidence={ECO:0000269|PubMed:29867142};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000250|UniProtKB:P29401};
CC   -!- PATHWAY: Carbohydrate metabolism. {ECO:0000269|PubMed:29867142}.
CC   -!- SUBUNIT: Probable heterodimer composed of AptA and AptB.
CC       {ECO:0000305|PubMed:29867142}.
CC   -!- SIMILARITY: Belongs to the transketolase family. {ECO:0000305}.
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DR   EMBL; CP000139; ABR38078.1; -; Genomic_DNA.
DR   RefSeq; WP_011964721.1; NC_009614.1.
DR   AlphaFoldDB; A6KXB4; -.
DR   SMR; A6KXB4; -.
DR   STRING; 435590.BVU_0359; -.
DR   EnsemblBacteria; ABR38078; ABR38078; BVU_0359.
DR   KEGG; bvu:BVU_0359; -.
DR   PATRIC; fig|435590.9.peg.371; -.
DR   eggNOG; COG3959; Bacteria.
DR   HOGENOM; CLU_009227_4_1_10; -.
DR   OMA; GQGYIAQ; -.
DR   OrthoDB; 1543182at2; -.
DR   BioCyc; BVUL435590:G1G59-378-MON; -.
DR   BRENDA; 2.2.1.13; 776.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd02012; TPP_TK; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005474; Transketolase_N.
DR   Pfam; PF00456; Transketolase_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Reference proteome; Thiamine pyrophosphate;
KW   Transferase.
FT   CHAIN           1..281
FT                   /note="Apulose-4-phosphate transketolase subunit A"
FT                   /id="PRO_0000446026"
SQ   SEQUENCE   281 AA;  31468 MW;  9979AF79B9CF5103 CRC64;
     MQVETLELQS EKNRKRLVEI VYKAKAGHIG GDLSCLNVLT ALYFDIMRVW PDKPKETKRD
     RFVMSKGHCV EALYVTLEAK GFISREVTDT LGEFGSILSG HPTIEVPGIE VNTGALGHGL
     SVGVGMAMAA KMDKADYKTY VLMGDGEQGE GSIYEAAMAG NQYKLDNLVA IIDRNRLQIS
     GTTEEVMSLE SMRDRWTAFG WDVLEMNGDE MEDIIRTFRS IDYTNKKPHL LISHTTKGKG
     VSYMEGIAKW HHGVPTAEQY EEAVREVSER IEKLEKENNG K