ID   APTB_PHOV8              Reviewed;         312 AA.
AC   A6KXB3;
DT   16-JAN-2019, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Apulose-4-phosphate transketolase subunit B {ECO:0000305};
DE            EC=2.2.1.13 {ECO:0000269|PubMed:29867142};
DE   AltName: Full=Apulose-4-phosphate transketolase C-terminal subunit {ECO:0000305};
GN   Name=aptB {ECO:0000305|PubMed:29867142};
GN   OrderedLocusNames=BVU_0358 {ECO:0000312|EMBL:ABR38077.1};
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 / NCTC
RC   11154;
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
RN   [2]
RP   FUNCTION, CATALYTIC ACTIVITY, PATHWAY, AND SUBUNIT.
RX   PubMed=29867142; DOI=10.1038/s41589-018-0067-7;
RA   Carter M.S., Zhang X., Huang H., Bouvier J.T., Francisco B.S.,
RA   Vetting M.W., Al-Obaidi N., Bonanno J.B., Ghosh A., Zallot R.G.,
RA   Andersen H.M., Almo S.C., Gerlt J.A.;
RT   "Functional assignment of multiple catabolic pathways for D-apiose.";
RL   Nat. Chem. Biol. 14:696-705(2018).
CC   -!- FUNCTION: Involved in catabolism of D-apiose. Catalyzes the transfer of
CC       the glycolaldehyde group from apulose-4-phosphate to D-glyceraldehyde
CC       3-phosphate, generating dihydroxyacetone phosphate and D-xylulose-5-
CC       phosphate. {ECO:0000269|PubMed:29867142}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=apulose 4-phosphate + D-glyceraldehyde 3-phosphate = D-
CC         xylulose 5-phosphate + dihydroxyacetone phosphate;
CC         Xref=Rhea:RHEA:57024, ChEBI:CHEBI:57642, ChEBI:CHEBI:57737,
CC         ChEBI:CHEBI:59776, ChEBI:CHEBI:141351; EC=2.2.1.13;
CC         Evidence={ECO:0000269|PubMed:29867142};
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000250|UniProtKB:P29401};
CC   -!- PATHWAY: Carbohydrate metabolism. {ECO:0000269|PubMed:29867142}.
CC   -!- SUBUNIT: Probable heterodimer composed of AptA and AptB.
CC       {ECO:0000305|PubMed:29867142}.
CC   -!- SIMILARITY: Belongs to the transketolase family. {ECO:0000305}.
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DR   EMBL; CP000139; ABR38077.1; -; Genomic_DNA.
DR   RefSeq; WP_005842354.1; NC_009614.1.
DR   AlphaFoldDB; A6KXB3; -.
DR   SMR; A6KXB3; -.
DR   STRING; 435590.BVU_0358; -.
DR   EnsemblBacteria; ABR38077; ABR38077; BVU_0358.
DR   KEGG; bvu:BVU_0358; -.
DR   eggNOG; COG3958; Bacteria.
DR   HOGENOM; CLU_009227_1_1_10; -.
DR   OMA; FYWVRTI; -.
DR   OrthoDB; 900125at2; -.
DR   BioCyc; BVUL435590:G1G59-377-MON; -.
DR   BRENDA; 2.2.1.13; 776.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Reference proteome; Thiamine pyrophosphate;
KW   Transferase.
FT   CHAIN           1..312
FT                   /note="Apulose-4-phosphate transketolase subunit B"
FT                   /id="PRO_0000446028"
SQ   SEQUENCE   312 AA;  33693 MW;  D404617DEF9D77A3 CRC64;
     MANNMIACRK SFTDTLLELA RQDKDIVAVT TDARGSVTLG DFAKELPAQF VECGIAEQDA
     VGISAGLAHS GKKVFVCGPA CFYVARSLEQ VKVDLAYSQN NVKILGVSGG VAYGALGATH
     HSLHDIAVLR TFPGMNIVLP CDARQTRKLV KLLVDYPEPV YVRVGRAAVP DVYENDDFEF
     VLGKANTLLD GTDLTIIAAG ETVYHAYQAG LMLREKGIQA RVLDMSSIKP VDVEAIRKAA
     EETGRIITVE EHSRFGGLGA IVVETLSENP VPVRIIGIPD ENVVHGNSHE IFAHYGLDKE
     GICKTALEFV KK