ID   ISDF_STAA8              Reviewed;         321 AA.
AC   Q2FZE5; Q8KQR4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Probable heme-iron transport system permease protein IsdF;
DE   AltName: Full=Iron-regulated surface determinant protein F;
DE   AltName: Full=Staphylococcal iron-regulated protein G;
GN   Name=isdF; Synonyms=sirG; OrderedLocusNames=SAOUHSC_01086;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=11952908; DOI=10.1046/j.1365-2958.2002.02850.x;
RA   Taylor J.M., Heinrichs D.E.;
RT   "Transferrin binding in Staphylococcus aureus: involvement of a cell wall-
RT   anchored protein.";
RL   Mol. Microbiol. 43:1603-1614(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       heme-iron. Responsible for the translocation of the substrate across
CC       the membrane (Probable). {ECO:0000305|PubMed:11952908}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Repressed by fur in the presence of iron.
CC       {ECO:0000269|PubMed:11952908}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD30201.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=ABD30201.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AY061874; AAL33764.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD30201.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; YP_499631.1; NC_007795.1.
DR   AlphaFoldDB; Q2FZE5; -.
DR   SMR; Q2FZE5; -.
DR   STRING; 1280.SAXN108_1129; -.
DR   EnsemblBacteria; ABD30201; ABD30201; SAOUHSC_01086.
DR   GeneID; 3919247; -.
DR   KEGG; sao:SAOUHSC_01086; -.
DR   PATRIC; fig|93061.5.peg.995; -.
DR   eggNOG; COG0609; Bacteria.
DR   HOGENOM; CLU_013016_0_3_9; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0033214; P:siderophore-dependent iron import into cell; IBA:GO_Central.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Iron; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..321
FT                   /note="Probable heme-iron transport system permease protein
FT                   IsdF"
FT                   /id="PRO_0000372460"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        253
FT                   /note="V -> VP (in Ref. 1; AAL33764)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   321 AA;  35078 MW;  6B5A94936E05BB3E CRC64;
     MMIKNKKKLL FLCLLVILIA TAYISFVTGT IKLSFNDLFT KFTTGSNEAV DSIIDLRLPR
     ILIALMVGAM LAVSGALLQA ALQNPLAEAN IIGVSSGALI MRALCMLFIP QLYFYLPLLS
     FIGGLIPFLI IILLHSKFRF NAVSMILVGV ALFVLLNGVL EILTQNPLMK IPQGLTMKIW
     SDVYILAVSA LLGLILTLLL SPKLNLLNLD DIQARSIGFN IDRYRWLTGL LAVFLASATV
     AIVGQLAFLG IIVHVVRKLV GGNYRVLIPF STVIGAWLLL VADLLGRVIQ PPLEIPANAI
     LMIVGGPMLI YLICQSQRNR I