ID   ISDF_STAAC              Reviewed;         322 AA.
AC   Q5HGV0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Probable heme-iron transport system permease protein IsdF;
DE   AltName: Full=Iron-regulated surface determinant protein F;
DE   AltName: Full=Staphylococcal iron-regulated protein G;
GN   Name=isdF; Synonyms=sirG; OrderedLocusNames=SACOL1144;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       heme-iron. Responsible for the translocation of the substrate across
CC       the membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Repressed by fur in the presence of iron. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW38023.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000046; AAW38023.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001548422.1; NC_002951.2.
DR   AlphaFoldDB; Q5HGV0; -.
DR   SMR; Q5HGV0; -.
DR   EnsemblBacteria; AAW38023; AAW38023; SACOL1144.
DR   KEGG; sac:SACOL1144; -.
DR   HOGENOM; CLU_013016_1_1_9; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Iron; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..322
FT                   /note="Probable heme-iron transport system permease protein
FT                   IsdF"
FT                   /id="PRO_0000372462"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   322 AA;  35175 MW;  9E982B59463096FD CRC64;
     MMIKNKKKLL FLCLLVILIA TAYISFVTGT IKLSFNDLFT KFTTGSNEAV DSIIDLRLPR
     ILIALMVGAM LAVSGALLQA ALQNPLAEAN IIGVSSGALI MRALCMLFIP QLYFYLPLLS
     FIGGLIPFLI IILLHSKFRF NAVSMILVGV ALFVLLNGVL EILTQNPLMK IPQGLTMKIW
     SDVYILAVSA LLGLILTLLL SPKLNLLNLD DIQARSIGFN IDRYRWLTGL LAVFLASATV
     AIVGQLAFLG IIVPHVVRKL VGGNYRVLIP FSTVIGAWLL LVADLLGRVI QPPLEIPANA
     ILMIVGGPML IYLICQSQRN RI