ISDF_STAAE
ID ISDF_STAAE Reviewed; 322 AA.
AC A6QG35;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Probable heme-iron transport system permease protein IsdF;
DE AltName: Full=Iron-regulated surface determinant protein F;
DE AltName: Full=Staphylococcal iron-regulated protein G;
GN Name=isdF; Synonyms=sirG; OrderedLocusNames=NWMN_1045;
OS Staphylococcus aureus (strain Newman).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=426430;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Newman;
RX PubMed=17951380; DOI=10.1128/jb.01000-07;
RA Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT analysis of staphylococcal genomes: polymorphism and evolution of two major
RT pathogenicity islands.";
RL J. Bacteriol. 190:300-310(2008).
RN [2]
RP IRON-REGULATED EXPRESSION.
RX PubMed=12574635; DOI=10.1126/science.1081147;
RA Mazmanian S.K., Skaar E.P., Gaspar A.H., Humayun M., Gornicki P.,
RA Jelenska J., Joachmiak A., Missiakas D.M., Schneewind O.;
RT "Passage of heme-iron across the envelope of Staphylococcus aureus.";
RL Science 299:906-909(2003).
CC -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC heme-iron. Responsible for the translocation of the substrate across
CC the membrane (Probable). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Repressed by fur in the presence of iron.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. FecCD subfamily. {ECO:0000305}.
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DR EMBL; AP009351; BAF67317.1; -; Genomic_DNA.
DR RefSeq; WP_001548422.1; NZ_CP023390.1.
DR AlphaFoldDB; A6QG35; -.
DR SMR; A6QG35; -.
DR EnsemblBacteria; BAF67317; BAF67317; NWMN_1045.
DR KEGG; sae:NWMN_1045; -.
DR HOGENOM; CLU_013016_1_1_9; -.
DR OMA; AMVYWSF; -.
DR Proteomes; UP000006386; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3470.10; -; 1.
DR InterPro; IPR037294; ABC_BtuC-like.
DR InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR PANTHER; PTHR30472; PTHR30472; 1.
DR Pfam; PF01032; FecCD; 1.
DR SUPFAM; SSF81345; SSF81345; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Iron; Membrane; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..322
FT /note="Probable heme-iron transport system permease protein
FT IsdF"
FT /id="PRO_0000372463"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 322 AA; 35175 MW; 9E982B59463096FD CRC64;
MMIKNKKKLL FLCLLVILIA TAYISFVTGT IKLSFNDLFT KFTTGSNEAV DSIIDLRLPR
ILIALMVGAM LAVSGALLQA ALQNPLAEAN IIGVSSGALI MRALCMLFIP QLYFYLPLLS
FIGGLIPFLI IILLHSKFRF NAVSMILVGV ALFVLLNGVL EILTQNPLMK IPQGLTMKIW
SDVYILAVSA LLGLILTLLL SPKLNLLNLD DIQARSIGFN IDRYRWLTGL LAVFLASATV
AIVGQLAFLG IIVPHVVRKL VGGNYRVLIP FSTVIGAWLL LVADLLGRVI QPPLEIPANA
ILMIVGGPML IYLICQSQRN RI
