ID   ISDF_STAAW              Reviewed;         322 AA.
AC   Q8NX64;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Probable heme-iron transport system permease protein IsdF;
DE   AltName: Full=Iron-regulated surface determinant protein F;
DE   AltName: Full=Staphylococcal iron-regulated protein G;
GN   Name=isdF; Synonyms=sirG; OrderedLocusNames=MW1016;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
RN   [2]
RP   INDUCTION BY HYDROGEN PEROXIDE AND HYPOCHLOROUS ACID.
RX   PubMed=18097052; DOI=10.4049/jimmunol.180.1.500;
RA   Palazzolo-Ballance A.M., Reniere M.L., Braughton K.R., Sturdevant D.E.,
RA   Otto M., Kreiswirth B.N., Skaar E.P., DeLeo F.R.;
RT   "Neutrophil microbicides induce a pathogen survival response in community-
RT   associated methicillin-resistant Staphylococcus aureus.";
RL   J. Immunol. 180:500-509(2008).
CC   -!- FUNCTION: Part of the binding-protein-dependent transport system for
CC       heme-iron. Responsible for the translocation of the substrate across
CC       the membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Repressed by fur in the presence of iron (By similarity).
CC       Up-regulated by hydrogen peroxide and to a lesser extent by
CC       hypochlorous acid. {ECO:0000250, ECO:0000269|PubMed:18097052}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. FecCD subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB94881.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000033; BAB94881.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001566586.1; NC_003923.1.
DR   AlphaFoldDB; Q8NX64; -.
DR   SMR; Q8NX64; -.
DR   EnsemblBacteria; BAB94881; BAB94881; BAB94881.
DR   KEGG; sam:MW1016; -.
DR   HOGENOM; CLU_013016_1_1_9; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.10.3470.10; -; 1.
DR   InterPro; IPR037294; ABC_BtuC-like.
DR   InterPro; IPR000522; ABC_transptr_permease_BtuC.
DR   PANTHER; PTHR30472; PTHR30472; 1.
DR   Pfam; PF01032; FecCD; 1.
DR   SUPFAM; SSF81345; SSF81345; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Iron; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..322
FT                   /note="Probable heme-iron transport system permease protein
FT                   IsdF"
FT                   /id="PRO_0000372468"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        61..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   322 AA;  35168 MW;  07C4BBAA8F086B0B CRC64;
     MMIKNKKKLL FLCLLVILIA TAYISFVTGT IKLSFNDLIT KFTTGNNEAV DSIIDLRLPR
     ILIALMVGAM LAVSGALLQA ALQNPLAEAN IIGVSSGALI MRALCMLFIP QLYFYLPLLS
     FIGGLIPFLI IILLHSKFRF NAVSMILVGV ALFVLLNGVL EILTQNPLMK IPQGLTMKIW
     SDVYILAVSA LLGLILTLLL SPKLNLLNLD DIQARSIGFN IDRYRWLTGL LAVFLASATV
     AIVGQLAFLG IIVPHVVRKL VGGNYRVLIP FSTVIGAWLL LVADLLGRVI QPPLEIPANA
     ILMIVGGPML IYLICQSQRN RI