ID   ISF1_YEAS2              Reviewed;         338 AA.
AC   C7GL43;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 25.
DE   RecName: Full=Increasing suppression factor 1;
DE   AltName: Full=Mitochondrial biogenesis regulation protein 3;
GN   Name=ISF1; Synonyms=MBR3; ORFNames=C1Q_01028;
OS   Saccharomyces cerevisiae (strain JAY291) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=574961;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JAY291;
RX   PubMed=19812109; DOI=10.1101/gr.091777.109;
RA   Argueso J.L., Carazzolle M.F., Mieczkowski P.A., Duarte F.M., Netto O.V.C.,
RA   Missawa S.K., Galzerani F., Costa G.G.L., Vidal R.O., Noronha M.F.,
RA   Dominska M., Andrietta M.G.S., Andrietta S.R., Cunha A.F., Gomes L.H.,
RA   Tavares F.C.A., Alcarde A.R., Dietrich F.S., McCusker J.H., Petes T.D.,
RA   Pereira G.A.G.;
RT   "Genome structure of a Saccharomyces cerevisiae strain widely used in
RT   bioethanol production.";
RL   Genome Res. 19:2258-2270(2009).
CC   -!- FUNCTION: Could influence the NAM7/UPF1 function, possibly at the level
CC       of mRNA turnover. Participates in mitochondrial biogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ISF1/MBR1 family. {ECO:0000305}.
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DR   EMBL; ACFL01000033; EEU08479.1; -; Genomic_DNA.
DR   AlphaFoldDB; C7GL43; -.
DR   Proteomes; UP000008073; Unassembled WGS sequence.
DR   InterPro; IPR031443; Mbr1.
DR   Pfam; PF17058; MBR1; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein.
FT   CHAIN           1..338
FT                   /note="Increasing suppression factor 1"
FT                   /id="PRO_0000408857"
FT   REGION          50..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         119
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32488"
SQ   SEQUENCE   338 AA;  37111 MW;  33C85E6F5479A39A CRC64;
     MIASEIFERG VQDPFCQDCD YEDETDVQSF LGSNDLNDFV NSKLASFSFE NSSKSNNSHH
     SSSTNAGNTS RHIGNHTIGH HLRKIKTAPH HLYGFVPANS TNNSNEPIRP SPRRIRANSS
     TLIHQLSRQS TRQSSLGDAA DSCFDHKCIK PRSRHSSCYG IPTHLYGLEK YVSSELDSLA
     VANDQSNDLT SPLTSVSTPA SNSNSYLNLN SSSAAYPSSY LSNEKNNRLK LISHGKISSN
     NVPGHSGNLN HYHRERTPSN LRRESFSLLS NGSSSSPLQT RNNSYSNSLV KSPSNSSLNT
     SVASSNEESS PHTSNCLEER NPRRKSFIKL SLASSFSN