ID   ISF1_YEAS7              Reviewed;         338 AA.
AC   A6ZME0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Increasing suppression factor 1;
DE   AltName: Full=Mitochondrial biogenesis regulation protein 3;
GN   Name=ISF1; Synonyms=MBR3; ORFNames=SCY_4252;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Could influence the NAM7/UPF1 function, possibly at the level
CC       of mRNA turnover. Participates in mitochondrial biogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ISF1/MBR1 family. {ECO:0000305}.
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DR   EMBL; AAFW02000020; EDN64470.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZME0; -.
DR   EnsemblFungi; EDN64470; EDN64470; SCY_4252.
DR   HOGENOM; CLU_070894_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   InterPro; IPR031443; Mbr1.
DR   Pfam; PF17058; MBR1; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein.
FT   CHAIN           1..338
FT                   /note="Increasing suppression factor 1"
FT                   /id="PRO_0000408859"
FT   REGION          50..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         119
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P32488"
SQ   SEQUENCE   338 AA;  37084 MW;  10817AF485B5A3F1 CRC64;
     MIASEIFERG VQDPFCQDCD YEDETDVQSF LGSNDLNDFV NSKLASFSFE NSSKSNNSHH
     SSSTNAGNTS RHIGNHTIGH HLRKIKTAPH HLYGFVPASS TNNSNEPIRP SPRRIRANSS
     TLIHQLSRQS TRQSSLGDAA DSCFDHKCIK PRSRHSSCYG IPTHLYGLEK YVSSELDSLA
     VANDQSNDLT SPLTSVSTPA SNSNSYLNLN SSSAAYPSSH LSNEKNNRLK LISHGKISSN
     NVPGHSGNLN HYHRERTPSN LRRESFSLLS NGSSSSPLQT RNNSYSNSLV KSPSNSSLNT
     SVASSNEESI PHTSNCLEER NPRRKSFIKL SLASSFSN