ISF1_YEAST
ID ISF1_YEAST Reviewed; 338 AA.
AC P32488; D6VZQ5;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Increasing suppression factor 1;
DE AltName: Full=Mitochondrial biogenesis regulation protein 3;
GN Name=ISF1; Synonyms=MBR3; OrderedLocusNames=YMR081C; ORFNames=YM9582.06C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=R100;
RX PubMed=8208248; DOI=10.1007/bf00284206;
RA Daignan-Fornier B., Nguyen C.C., Reisdorf P., Lemeignan B.,
RA Bolotin-Fukuhara M.;
RT "MBR1 and MBR3, two related yeast genes that can suppress the growth defect
RT of hap2, hap3 and hap4 mutants.";
RL Mol. Gen. Genet. 243:575-583(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=7506349; DOI=10.1007/bf00277347;
RA Altamura N., Dujardin G., Groudinsky O., Slonimski P.P.;
RT "Two adjacent nuclear genes, ISF1 and NAM7/UPF1, cooperatively participate
RT in mitochondrial functions in Saccharomyces cerevisiae.";
RL Mol. Gen. Genet. 242:49-56(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP INDUCTION.
RX PubMed=9199511; DOI=10.1016/s0014-5793(97)00497-3;
RA Altamura N., de Pinto B., Castaldo R., Verdiere J.;
RT "The transcription of NAM7/UPF1 is enhanced in the absence of Cyp1p/Hap1p
RT concomitant with the appearance of an ISF1-NAM7 cotranscript in
RT Saccharomyces cerevisiae.";
RL FEBS Lett. 409:96-100(1997).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-119, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Could influence the NAM7/UPF1 function, possibly at the level
CC of mRNA turnover. Participates in mitochondrial biogenesis.
CC {ECO:0000269|PubMed:7506349, ECO:0000269|PubMed:8208248}.
CC -!- INDUCTION: Repressed by glucose. Cotranscribed with NAM7 in the absence
CC of CYP1. {ECO:0000269|PubMed:9199511}.
CC -!- SIMILARITY: Belongs to the ISF1/MBR1 family. {ECO:0000305}.
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DR EMBL; X72671; CAA51221.1; -; Genomic_DNA.
DR EMBL; X72931; CAA51435.1; -; Genomic_DNA.
DR EMBL; Z49259; CAA89227.1; -; Genomic_DNA.
DR EMBL; AY692919; AAT92938.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09979.1; -; Genomic_DNA.
DR PIR; S45578; S45578.
DR RefSeq; NP_013798.1; NM_001182580.1.
DR AlphaFoldDB; P32488; -.
DR BioGRID; 35257; 36.
DR STRING; 4932.YMR081C; -.
DR iPTMnet; P32488; -.
DR MaxQB; P32488; -.
DR PaxDb; P32488; -.
DR EnsemblFungi; YMR081C_mRNA; YMR081C; YMR081C.
DR GeneID; 855105; -.
DR KEGG; sce:YMR081C; -.
DR SGD; S000004686; ISF1.
DR VEuPathDB; FungiDB:YMR081C; -.
DR eggNOG; ENOG502ST5N; Eukaryota.
DR HOGENOM; CLU_070894_0_0_1; -.
DR InParanoid; P32488; -.
DR OMA; SEACDNE; -.
DR BioCyc; YEAST:G3O-32783-MON; -.
DR PRO; PR:P32488; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; P32488; protein.
DR GO; GO:0009060; P:aerobic respiration; IGI:SGD.
DR InterPro; IPR031443; Mbr1.
DR Pfam; PF17058; MBR1; 2.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..338
FT /note="Increasing suppression factor 1"
FT /id="PRO_0000096272"
FT REGION 50..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 119
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
SQ SEQUENCE 338 AA; 37110 MW; 34A344D99835275E CRC64;
MIASEIFERG VQDPFCQDCD YEDETDVQSF LGSNDLNDFV NSKLASFSFQ NSSKSNNSHH
SSSTNAGNTS RHIGNHTIGH HLRKIKTAPH HLYGFVPANS TNNSNEPIRP SPRRIRANSS
TLIHQLSRQS TRQSSLGDAA DSCFDHKCIK PRSRHSSCYG IPTHLYGLEK YVSSELDSLA
VANDQSNDLT SPLTSVSTPA SNSNSYLNLN SSSAAYPSSY LSNEKNNRLK LISHGKISSN
NVPGHSGNLN HYHRERTPSN LRRESFSLLS NGSSSSPLQT RNNSYSNSLV KSPSNSSLNT
SVASSNEESS PHTSNCLEER NPRRKSFIKL SLASSFSN
