APTF4_CAEEL
ID APTF4_CAEEL Reviewed; 486 AA.
AC Q19863;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Transcription factor aptf-4 {ECO:0000303|PubMed:27176626};
GN Name=aptf-4 {ECO:0000312|WormBase:F28C6.1};
GN ORFNames=F28C6.1 {ECO:0000312|WormBase:F28C6.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=27176626; DOI=10.1371/journal.pgen.1006048;
RA Budirahardja Y., Tan P.Y., Doan T., Weisdepp P., Zaidel-Bar R.;
RT "The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and
RT Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis.";
RL PLoS Genet. 12:e1006048-e1006048(2016).
CC -!- FUNCTION: Sequence-specific DNA-binding protein that interacts with
CC enhancer elements to regulate transcription of selected genes (By
CC similarity). Required for neuroblast and epidermal morphogenesis,
CC perhaps acting in cooperation with transcription factor aptf-2
CC (PubMed:27176626). {ECO:0000250|UniProtKB:P05549,
CC ECO:0000269|PubMed:27176626}.
CC -!- SUBUNIT: Binds DNA as a dimer. {ECO:0000250|UniProtKB:P05549}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:27176626}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes embryonic
CC lethality and morphological defects in larva (PubMed:27176626).
CC Embryonic lethality is exacerbated on the transcription factor aptf-2
CC mutant background (PubMed:27176626). {ECO:0000269|PubMed:27176626}.
CC -!- SIMILARITY: Belongs to the AP-2 family. {ECO:0000303|PubMed:27176626}.
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DR EMBL; BX284602; CAA92669.1; -; Genomic_DNA.
DR PIR; T21481; T21481.
DR RefSeq; NP_495818.1; NM_063417.5.
DR AlphaFoldDB; Q19863; -.
DR IntAct; Q19863; 4.
DR STRING; 6239.F28C6.1; -.
DR PaxDb; Q19863; -.
DR EnsemblMetazoa; F28C6.1.1; F28C6.1.1; WBGene00009202.
DR GeneID; 174376; -.
DR KEGG; cel:CELE_F28C6.1; -.
DR UCSC; F28C6.1; c. elegans.
DR CTD; 174376; -.
DR WormBase; F28C6.1; CE03272; WBGene00009202; aptf-4.
DR eggNOG; KOG3811; Eukaryota.
DR GeneTree; ENSGT00950000182848; -.
DR HOGENOM; CLU_561689_0_0_1; -.
DR InParanoid; Q19863; -.
DR OMA; LMADICE; -.
DR OrthoDB; 1750433at2759; -.
DR PhylomeDB; Q19863; -.
DR Reactome; R-CEL-3232118; SUMOylation of transcription factors.
DR Reactome; R-CEL-8866904; Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
DR Reactome; R-CEL-8866907; Activation of the TFAP2 (AP-2) family of transcription factors.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00009202; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:WormBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:WormBase.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:WormBase.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004979; TF_AP2.
DR InterPro; IPR013854; TF_AP2_C.
DR PANTHER; PTHR10812; PTHR10812; 1.
DR Pfam; PF03299; TF_AP-2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..486
FT /note="Transcription factor aptf-4"
FT /id="PRO_0000453376"
FT REGION 25..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..430
FT /note="H-S-H (helix-span-helix), dimerization"
FT /evidence="ECO:0000250|UniProtKB:P05549"
FT COMPBIAS 25..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 486 AA; 55618 MW; 759CF127A26BFA61 CRC64;
MSYYPYYQTE NSDYSSFNSL MADICEPSPS SSSSRKRPAD SENGNSAKMP VVIPMQPVQN
FTMQYPIDNG WQNFNMIHQV YNNNNMNQPG YGWVGQPPPM PQDFYKARPG QTVTPPMNEF
HNAHGTQQTP NDNSGNLPIS SVMYTPESDL STTSANFTPD WNTTTNGPCN QEKRNKENLF
PNDDTSSGKL FDYFLTNTER ENESENNIPH PYNKAVFPTF GVPVSSDGNV VAEVVDGRLP
AVGTRSKYDL TVDELRRRCG APEHMNQSAL YCFFRKSKKK EAINRVKKVL TDYNITVRTM
QRQRKVTCFS PFLEEEATAL ARDLDSITEE FLPIDAIALE MLEKLIFNNK NLDICLRILK
NTNKTITRVI KTLEVRQPKI TGQKEKLKGN SLDLSYHNFS LTTHGFGHPN SLSHYRSYQK
IVEQAALYCE KMQKGASLPS KEYLIPGQKP FENMSNEFFV EWRMRSYHKK ARKEMLDFNQ
AYSRSS
