ISH1_SCHPO
ID ISH1_SCHPO Reviewed; 684 AA.
AC Q9Y7X6; Q09149;
DT 13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Stress response protein ish1;
GN Name=ish1; Synonyms=isp1; ORFNames=SPBC365.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BAP1;
RA Turi T.G., Mueller U.W., Sazer S., Rose J.K.;
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, SUBUNIT, INTERACTION WITH BIS1, AND SUBCELLULAR LOCATION.
RX PubMed=11751918; DOI=10.1074/jbc.m110686200;
RA Taricani L., Tejada M.L., Young P.G.;
RT "The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-
RT responsive nuclear envelope protein.";
RL J. Biol. Chem. 277:10562-10572(2002).
CC -!- FUNCTION: Has a role in maintaining cell viability during stationary
CC phase induced by stress response. Activated by the spc1 MAPK pathway.
CC {ECO:0000269|PubMed:11751918}.
CC -!- SUBUNIT: Homodimer, and heterodimer with bis1.
CC {ECO:0000269|PubMed:11751918}.
CC -!- INTERACTION:
CC Q9Y7X6; O59793: bis1; NbExp=4; IntAct=EBI-1559673, EBI-1559662;
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:11751918}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC49262.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U38783; AAC49262.1; ALT_FRAME; Genomic_DNA.
DR EMBL; CU329671; CAB44764.1; -; Genomic_DNA.
DR PIR; T40319; T40319.
DR RefSeq; NP_596041.1; NM_001021951.2.
DR AlphaFoldDB; Q9Y7X6; -.
DR SMR; Q9Y7X6; -.
DR BioGRID; 277475; 17.
DR IntAct; Q9Y7X6; 3.
DR STRING; 4896.SPBC365.12c.1; -.
DR iPTMnet; Q9Y7X6; -.
DR MaxQB; Q9Y7X6; -.
DR PaxDb; Q9Y7X6; -.
DR PRIDE; Q9Y7X6; -.
DR EnsemblFungi; SPBC365.12c.1; SPBC365.12c.1:pep; SPBC365.12c.
DR GeneID; 2540959; -.
DR KEGG; spo:SPBC365.12c; -.
DR PomBase; SPBC365.12c; ish1.
DR VEuPathDB; FungiDB:SPBC365.12c; -.
DR eggNOG; ENOG502RNIV; Eukaryota.
DR HOGENOM; CLU_402333_0_0_1; -.
DR InParanoid; Q9Y7X6; -.
DR OMA; NACNIYR; -.
DR PhylomeDB; Q9Y7X6; -.
DR PRO; PR:Q9Y7X6; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005635; C:nuclear envelope; IDA:PomBase.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IDA:PomBase.
DR InterPro; IPR018803; Ish1/Msc1-like.
DR Pfam; PF10281; Ish1; 1.
PE 1: Evidence at protein level;
KW Membrane; Nucleus; Reference proteome.
FT CHAIN 1..684
FT /note="Stress response protein ish1"
FT /id="PRO_0000221231"
FT CONFLICT 418
FT /note="S -> C (in Ref. 1; AAC49262)"
FT /evidence="ECO:0000305"
FT CONFLICT 490
FT /note="V -> E (in Ref. 1; AAC49262)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 684 AA; 75699 MW; 884CE69714BC7FAB CRC64;
MRSRSVASLG VLLAIVFYIF TYGFSTYRKN DTSAVKTWLE EHSIPYGSRS SPSDFQQFIS
ESYDSLVPNL DKWSGHNLNS WLGKKTESSY LDAISNKIRK TGRKLSGSVE DARDATQEAW
ESQKASLFES WSDSQLRAFL ARHSPQFAAK EKKGILEKLS PASLRETAAK EYDALTSKLG
NTGDWIYDTW SDNELRTWLH DVGVPISSHE STRSHLLRKL KNYISTKADE AQPSVEAVKG
KASEKAKQAG EFVSDKAGDA KELVNEKSSE AGQYAGQKME EGGELLQEIS KRRGRFGNWW
ANSGLKAYFD AHGIPAYQPS PIDQFYAHLR RQYYLKTNGY QALKSKAYEE ASNVADSASS
IASNVASGAT EAYQGAASGA SRFTEGAKTA AESVTSAFEH NKDTATSKAK QMKGKAASLG
STASEKVGEA ADYAAETASK VASKAASKVR ETIDETIIER WQDSKLKEFL FLRGVPVPQR
STKDQLLDLV RKHFNKGAVP NWAAYFDTLS SKELSAWIKE YKKHYHGKLH PSKDREHLFQ
NACNIYRAIA EKADKSVLQS IQSKFPKATV PGYDSWSNED LKSALKEYGD SIGKVFNRKD
AIERLKRHDI LFYGPVVADK AKSGVSGFLR RVASFMGFGT RDVAEIKLGE NIQKVKDTAS
KASSAVSSAG DYVETNVKKA QRVL
