ISK11_MOUSE
ID ISK11_MOUSE Reviewed; 88 AA.
AC Q09TK7; B9EJS7; Q3UW03;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Serine protease inhibitor Kazal-type 11;
DE Flags: Precursor;
GN Name=Spink11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=FVB/N; TISSUE=Epididymis;
RX PubMed=16930550; DOI=10.1016/j.bbrc.2006.08.023;
RA Jalkanen J., Kotimaeki M., Huhtaniemi I., Poutanen M.;
RT "Novel epididymal protease inhibitors with Kazal or WAP family domain.";
RL Biochem. Biophys. Res. Commun. 349:245-254(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable serine protease inhibitor.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in epydiymis, in the caput. Also
CC expressed in seminal vesicles. {ECO:0000269|PubMed:16930550}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABD93326.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DQ437331; ABD93326.1; ALT_INIT; mRNA.
DR EMBL; AK136741; BAE23116.1; -; mRNA.
DR EMBL; BC147524; AAI47525.1; -; mRNA.
DR EMBL; BC147541; AAI47542.1; -; mRNA.
DR RefSeq; NP_001041682.2; NM_001048217.3.
DR AlphaFoldDB; Q09TK7; -.
DR SMR; Q09TK7; -.
DR STRING; 10090.ENSMUSP00000095194; -.
DR GlyGen; Q09TK7; 1 site.
DR PaxDb; Q09TK7; -.
DR PRIDE; Q09TK7; -.
DR ProteomicsDB; 268999; -.
DR DNASU; 433181; -.
DR Ensembl; ENSMUST00000239421; ENSMUSP00000159307; ENSMUSG00000073573.
DR GeneID; 433181; -.
DR KEGG; mmu:433181; -.
DR UCSC; uc008euu.2; mouse.
DR CTD; 433181; -.
DR MGI; MGI:3588289; Spink11.
DR VEuPathDB; HostDB:ENSMUSG00000073573; -.
DR GeneTree; ENSGT00940000164814; -.
DR InParanoid; Q09TK7; -.
DR OrthoDB; 1636538at2759; -.
DR PhylomeDB; Q09TK7; -.
DR BioGRID-ORCS; 433181; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q09TK7; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q09TK7; protein.
DR Bgee; ENSMUSG00000073573; Expressed in proximal tubule and 4 other tissues.
DR ExpressionAtlas; Q09TK7; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR Pfam; PF00050; Kazal_1; 1.
DR SUPFAM; SSF100895; SSF100895; 1.
DR PROSITE; PS00282; KAZAL_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Protease inhibitor; Reference proteome;
KW Secreted; Serine protease inhibitor; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..88
FT /note="Serine protease inhibitor Kazal-type 11"
FT /id="PRO_0000302142"
FT DOMAIN 32..87
FT /note="Kazal-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT SITE 49..50
FT /note="Reactive bond"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 38..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 47..66
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT DISULFID 55..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ SEQUENCE 88 AA; 10090 MW; 3B6A95A0412ACC13 CRC64;
MSSTWIKFLF ILTLVLLPYF VAESAVASPE SLRKVPNCTL YKSESDCSRT LIPVCADNQM
TYYNACYFCL EQLVSPIKYK YHGICTKE
